DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and ush2a

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	522	Identity:	83/522 - (15%)
Similarity:	163/522 - (31%)	Gaps:	176/522 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRMSITH 189
            |::..|..|.:|.:.|:                  :::|...|:.....:...::.....:.::|
Zfish  1068 PQQQPPPLGRVLNSTTI------------------ELSWRTPDSPNSNALMYTLLRDTQIIHVSH 1114

  Fly   190 AEKRAWILRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPDILDYPTSTDMV-------IRE 247
            ::.....:...|...|....|..|:.|..::|.                ||:.:|       :.|
Zfish  1115 SQHPFGTMHFIDTALSPYTLYSYQLITSNIRSN----------------TSSSVVTLRTLSAVPE 1163

  Fly   248 GSNVTLKCAATGSP-TPTITWRREGGELIPLPN----------GAEAVAYNG-----SFLTIAKV 296
            ...:.|.......| :.:..|........|:.|          |.:.:.|.|     :...:...
Zfish  1164 QEELQLTLVGRAKPNSASFNWTEPLNTTGPIDNYTLSSIQDLSGEKRIYYTGLQTEATAEELQPF 1228

  Fly   297 NRLNMGAYLC------------IASNGIPP---------TVSKRVMLIVHFPPMIWIQNQLVGAA 340
            .|.|.....|            :.:..|||         |:....:.:...||:  :.|   |..
Zfish  1229 TRYNFSLKACTDGGCARSESLVVQTAQIPPEQQPAPKITTLGSSQLKVDWEPPV--LPN---GII 1288

  Fly   341 LTQNITLECQSEAYPKSINY-----------WMK--------NDTIIVPGERFVPETFESGYKIT 386
            :...:.::..:|....:.:|           |:.        |:..:.|     ||:
Zfish  1289 IRYELFMQLLNELQRNASSYGTEQRVFLSSGWLNPRPSLSSANENALTP-----PES-------- 1340

  Fly   387 MRLTIYEVDIQDFGAYRC------VAKNSLGD------TDGAIKLYHIPQTTTMTTMAPTVSINT 439
               |:...::|.|..||.      :|.:.|.|      .:|..:....||.:.:::.:..||..|
Zfish  1341 ---TVVVSNLQPFSTYRFRVLTVNMAGSVLSDWAVGRTAEGVPEYMAPPQVSAVSSSSLRVSWET 1402

  Fly   440 VPVVLVKYN-KEQRYGSSQNSNTNPYN-------FNPGNSQQNTKLQRG---------------- 480
            .....|:.. .|.|....|...:|||.       ...|::|:::....|
Zfish  1403 PRDKDVRGEVTEYRVNLHQEQMSNPYAPPIVTQVLYSGSAQEHSYTAGGLKAYEEYSFTVTVCNR 1467

  Fly   481 ---KSNSKGSDQ----SPSGLN------------NVFVGATSSLWNSQD--HHSSSSSSSSASSR 524
               .|:|..|.:    :|:||.            |||..|.:.| |...  :|...:..|.:.::
Zfish  1468 QGCVSSSPASGRTLPSAPAGLRAPGLRPLNMTAMNVFWDAPAEL-NGPPPLYHVERTDVSLSDAQ 1531

  Fly   525 GR 526
            |:
Zfish  1532 GQ 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	10/92 (11%)
		IG_like	137..230	CDD:214653	10/92 (11%)
		IG_like	240..324	CDD:214653	18/127 (14%)
		IGc2	247..310	CDD:197706	12/90 (13%)
		Ig	327..419	CDD:299845	20/122 (16%)
		IG_like	343..420	CDD:214653	16/107 (15%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020	10/75 (13%)
		FN3	1264..1375	CDD:238020	20/131 (15%)
		FN3	1386..1469	CDD:214495	15/82 (18%)
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900