DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and robo4

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	464	Identity:	106/464 - (22%)
Similarity:	164/464 - (35%)	Gaps:	124/464 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VSIIC-LSLALPGCA-------AQESDDEGELHHLDQMHHQHQDFIIGESEEHDHIAHHLAEMQN 107
            |:.:| .|.|:..||       ||.|:.:|.|.|  ::.||.        ..|...||     :.
Zfish    10 VAWLCTCSKAVRQCACPPDEQVAQRSEGKGHLRH--RLMHQR--------ASHRDRAH-----RR 59

  Fly   108 KDELLEDIREDTVVNAIPEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLR------- 165
            |...|           :.|.:||:......:|.|.|...|.|.|..:......|.|||
Zfish    60 KGSRL-----------VSEINLPRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDT 113

  Fly   166 --VDTQTILTI-----------------QNH-----VITKNHRMSITHAEKRAWILRIRDVKESD 206
              :|.|:...:                 |:|     .|..|   ||.:|..|...|.|..::|
Zfish   114 DKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHN---SIGNATSRNASLHIAALRE-- 173

  Fly   207 KGWYMCQINTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTLKCA-ATGSPTPTITWRRE 270
                                |..|.|        :|:.:..|...|:.|: ..|.|.|.:|||::
Zfish   174 --------------------DFRVQP--------SDVEVAIGEMATINCSPPVGHPEPNVTWRKD 210

  Fly   271 GGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQ 335
            |   |.:.:..|........|.||...:.:.|.|.|||||.|....|:...|.|...|::..:.:
Zfish   211 G---ILINSSNEHYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPE 272

  Fly   336 LVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPGERFVPETFESGYKITMRLTIYEVDIQDFG 400
            .|...|.::....|:::..|.....|.:....: |..|::.....|       |.|:.|..||.|
Zfish   273 DVSVQLGESAQFFCEADGDPMPSIEWSREQGPL-PNGRYLINPDHS-------LQIHYVTAQDMG 329

  Fly   401 AYRCVAKNSLG----------DTDGAIKLYHIPQTTTMTTMAPTVSINTVPVVLVKYNKEQRYGS 455
            .|.|..:|.||          :..|..:|..:.:..:    |..||:..|.|:....|..|....
Zfish   330 RYSCTVENKLGVSVASAQLLVEDAGGTRLRDLHKELS----ALRVSLENVTVMSTASNMSQVMWK 390

  Fly   456 SQNSNTNPY 464
            .|:..:.|:
Zfish   391 LQSFGSQPH 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	24/123 (20%)
		IG_like	137..230	CDD:214653	24/123 (20%)
		IG_like	240..324	CDD:214653	26/84 (31%)
		IGc2	247..310	CDD:197706	20/63 (32%)
		Ig	327..419	CDD:299845	21/101 (21%)
		IG_like	343..420	CDD:214653	18/86 (21%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	23/101 (23%)
		I-set	71..168	CDD:254352	22/99 (22%)
		I-set	175..261	CDD:254352	28/96 (29%)
		Ig2_Robo	177..261	CDD:143201	28/94 (30%)
		I-set	265..350	CDD:254352	20/92 (22%)
		Ig	282..350	CDD:299845	17/75 (23%)
		FN3	373..448	CDD:214495	6/27 (22%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900