DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and TMIGD1

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_996663.1	Gene:	TMIGD1 / 388364	HGNCID:	32431	Length:	262	Species:	Homo sapiens

Alignment Length:	179	Identity:	50/179 - (27%)
Similarity:	79/179 - (44%)	Gaps:	40/179 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 GSNVTLKCAATG-SPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIAS-- 309
            ||..:|.||... :....:.|.||.|. :.|.:|                |::|..: :|::|
Human    47 GSQASLICAVQNHTREEELLWYREEGR-VDLKSG----------------NKINSSS-VCVSSIS 93

  Fly   310 ---NGIPPT--------VSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMK 363
               |||..|        ||..|:|.|.|||:: ..|.........|:.|.|..:|.|::...|.|
Human    94 ENDNGISFTCRLGRDQSVSVSVVLNVTFPPLL-SGNDFQTVEEGSNVKLVCNVKANPQAQMMWYK 157

  Fly   364 NDTI--IVPGERFVPETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSL 410
            |.::  :......:.:|.||     .:|:|.:|:..|.|.|.|:||:||
Human   158 NSSLLDLEKSRHQIQQTSES-----FQLSITKVEKPDNGTYSCIAKSSL 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845
		IG_like	137..230	CDD:214653
		IG_like	240..324	CDD:214653	23/89 (26%)
		IGc2	247..310	CDD:197706	15/67 (22%)
		Ig	327..419	CDD:299845	25/86 (29%)
		IG_like	343..420	CDD:214653	22/70 (31%)
TMIGD1	NP_996663.1	IG	131..212	CDD:214652	22/76 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11661
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910