DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Dscam2

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	94/356 - (26%)
Similarity:	142/356 - (39%)	Gaps:	71/356 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 EDTVVNAIPEKDLPKFGELLQNVTVPVSREAVLQC-VVDNLQTYKIAWLRVDTQTILTIQNHVIT 180
            |.||:  :|.|..|....:||   :.:...|.|.| ||.......|.| |.|.:.|...|:
  Fly   605 EVTVI--VPPKLSPFQTNILQ---LNMGDRASLTCSVVKGDLPLTINW-RKDGRPIDPTQH---- 659

  Fly   181 KNHRMSITHAEKRAWILRIRDVKESDKGWYMCQINTDPMK---SQVGYLDVVVPPDILDYPTSTD 242
                ||:...::...||.|.::.....|.|.|.:.....:   ||.  |.|.|||..:..|  .|
  Fly   660 ----MSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQA--LLVNVPPRWIVEP--VD 716

  Fly   243 MVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAY-------------NGSFLTIA 294
            ..:....::.|.|.|.|.|||:|.|::        ..|:::..|             |||.| :.
  Fly   717 ANVERNRHIMLHCQAQGVPTPSIVWKK--------ATGSKSGEYEEVRERPFTKLLGNGSLL-LQ 772

  Fly   295 KVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSIN 359
            .|.....|.|||.|:|||...:.|.:.|.|:..|.....::.|.........|:| :.:..|.||
  Fly   773 HVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQC-AVSGDKPIN 836

  Fly   360 -YWMKNDTIIVPGERFV-PETFESGYKITMR-----------LTIYEVDIQDFGAYRCVAKNSLG 411
             .||::      |:..: |.|   .|||:::           |.|..||..|.|.|.|.|.|..|
  Fly   837 IVWMRS------GKNTLNPST---NYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYG 892

  Fly   412 DTDGAIKLY----HIPQTTTMTTMAPTVSIN 438
            :....::|.    .:|.:.....|..:.|:|
  Fly   893 NDQQLVQLQVQEPPLPPSVLEAAMISSRSVN 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	24/96 (25%)
		IG_like	137..230	CDD:214653	24/96 (25%)
		IG_like	240..324	CDD:214653	27/96 (28%)
		IGc2	247..310	CDD:197706	21/75 (28%)
		Ig	327..419	CDD:299845	26/104 (25%)
		IG_like	343..420	CDD:214653	24/89 (27%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352
		Ig	247..327	CDD:299845
		I-set	332..418	CDD:254352
		IGc2	344..407	CDD:197706
		IG_like	432..517	CDD:214653
		IGc2	436..507	CDD:197706
		I-set	521..610	CDD:254352	3/6 (50%)
		IGc2	533..597	CDD:197706
		Ig	630..699	CDD:143165	19/77 (25%)
		IG_like	714..802	CDD:214653	28/98 (29%)
		Ig	725..802	CDD:299845	26/85 (31%)
		Ig	823..894	CDD:143165	24/80 (30%)
		FN3	906..1006	CDD:238020	4/18 (22%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810