DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and wrapper

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_477404.1	Gene:	wrapper / 37555	FlyBaseID:	FBgn0025878	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	117/540 - (21%)
Similarity:	192/540 - (35%)	Gaps:	124/540 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LAEMQNKDELLEDIREDTVVNAIPEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRV 166
            |.::|.:.:...|:.     |:...|.:|...:..:|.||.      |.|.::....| :.|.|
  Fly    18 LGQVQAELDFNNDLE-----NSQKFKSIPTTVKTYENDTVQ------LPCTLNTPFRY-VRWHR- 69

  Fly   167 DTQTILTIQNHVITKNHRMSITHAEKRAW---ILRIRDVKESDKGWYMCQINTDPMKSQVGY--- 225
            |...::..::..:....|:.:       |   .|::.:|:.||.|.|.|::|:|.     |:
  Fly    70 DDVALVDSRHPELPPPDRIML-------WPNGSLQVANVQSSDTGDYYCEMNSDS-----GHVVQ 122

  Fly   226 ---LDVVVPPDILDYPTS-TDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAY 286
               ::|.:.|.:|..|:. |:.  |.|:...:.|.|.|.|.|.||||..|..:.|..|..
  Fly   123 QHAIEVQLAPQVLIEPSDLTEQ--RIGAIFEVVCEAQGVPQPVITWRLNGNVIQPQSNTG----- 180

  Fly   287 NGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQS 351
            |...|.:...:|...|...|:||||:.......|.|.|.|.|.:.|...:|...|.....|||..
  Fly   181 NRQSLILEIKSRNQAGLIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSRAHLECIV 245

  Fly   352 EAYPKSINYWMKNDTIIVPGERFVPETFESGYK-----------ITMRLTIYEVDIQDFGAYRCV 405
            ||.|.:...|..:...:..|..  ..|.||..:           :...|.:..|...|.|.|.|.
  Fly   246 EAAPAATVKWFHHGLPVALGAH--STTHESELQTNRSVDHYVNAVRHMLVVKSVRNADMGQYECR 308

  Fly   406 AKNSLGDTDGAIKLYHIP------------QTTTMTTMAPTVSINTVPVVLVKYNKEQRYGSSQN 458
            |.|.:....|:::|...|            .:|:...:..|.|:..:....:|:.:......::.
  Fly   309 ASNQISVKSGSVELTGRPMPCLFKINPGTQSSTSHVLVWQTESLLPIMEFKLKFRQIPSNNVTRQ 373

  Fly   459 SNTN------PYNFNPGNSQQNTKLQRGKSNSKGSDQSPSGLNNVFVGATSSL-WNSQDHHSSSS 516
            ..||      |.....|.....|....|        ..|:.|..|.|.|.:|. |
  Fly   374 VRTNWTELTIPAQATNGLIYITTYTLHG--------LQPASLYEVSVLARNSFGW---------- 420

  Fly   517 SSSSASSRGRDHHQQQHHQQQQQNHGSDHGASYR-SDGKSPHLTNHDAKS-LTDDLDRMQDLKGW 579
                                      ||:....| :.|....|.|:..:| |.||...    :.:
  Fly   421 --------------------------SDNSKIVRFATGGEVELPNYSTESELQDDFTE----EDF 455

  Fly   580 ASRLSPISPILGLSMILGVG 599
            .:.::..|.:|..||:...|
  Fly   456 HNEITQRSEVLSASMMFNSG 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	22/101 (22%)
		IG_like	137..230	CDD:214653	22/101 (22%)
		IG_like	240..324	CDD:214653	26/84 (31%)
		IGc2	247..310	CDD:197706	19/62 (31%)
		Ig	327..419	CDD:299845	24/102 (24%)
		IG_like	343..420	CDD:214653	20/87 (23%)
wrapper	NP_477404.1	Ig	41..124	CDD:299845	22/102 (22%)
		IG_like	41..118	CDD:214653	21/96 (22%)
		IG_like	145..218	CDD:214653	25/77 (32%)
		Ig	147..219	CDD:299845	24/76 (32%)
		I-set	224..323	CDD:254352	23/100 (23%)
		IGc2	236..314	CDD:197706	19/79 (24%)
		FN3	339..431	CDD:238020	20/135 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810