DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Lac

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	90/301 - (29%)
Similarity:	148/301 - (49%)	Gaps:	12/301 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTI-LTIQNHVITKNHRMSITH-AEK 192
            |....:.|.....:.......|.|...:.|.:.:|:.|:..: |:..:.::.|:.|.|:.: ...
  Fly    29 PTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNS 93

  Fly   193 RAWILRIRDVKESDKGWYMCQ--INTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTLKC 255
            ..:.|:|:|::|:|.|.|.||  |:|....|....|.|..||.|.|..|.: :|..|||.|.::|
  Fly    94 STYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQS-VVASEGSEVQMEC 157

  Fly   256 AATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRV 320
            .|:|.||||||||||...::|    .::..|.|:.|.|..|.:.:.|.|.|:|.||:.....:.:
  Fly   158 YASGYPTPTITWRRENNAILP----TDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNI 218

  Fly   321 MLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPGERFVPETFESGYKI 385
            .:.|.|.|:|.:....:|.||..::.|||..||||.....|.|:|..:...:.:....|.:..:.
  Fly   219 NVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATADEY 283

  Fly   386 T-MRLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYH--IP 423
            | ..|.:..|:.:.:|.|.|.|.|..|:.:..:.|:.  ||
  Fly   284 TDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIP 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	24/96 (25%)
		IG_like	137..230	CDD:214653	24/96 (25%)
		IG_like	240..324	CDD:214653	30/83 (36%)
		IGc2	247..310	CDD:197706	27/62 (44%)
		Ig	327..419	CDD:299845	25/92 (27%)
		IG_like	343..420	CDD:214653	20/77 (26%)
Lac	NP_523713.2	IG_like	36..131	CDD:214653	23/94 (24%)
		FR1	37..50	CDD:409353	0/12 (0%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	0/6 (0%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	0/3 (0%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	1/13 (8%)
		Ig strand C'	68..72	CDD:409353	0/3 (0%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	10/30 (33%)
		Ig strand D	84..90	CDD:409353	2/5 (40%)
		Ig strand E	94..102	CDD:409353	2/7 (29%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	2/7 (29%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	33/78 (42%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	3/3 (100%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	24/90 (27%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	1/3 (33%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8424
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	7	6.920