DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Prtg

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001032740.2	Gene:	Prtg / 315806	RGDID:	1307157	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	109/508 - (21%)
Similarity:	169/508 - (33%)	Gaps:	109/508 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 FGELL-----QNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHV-ITKNHRMSITHA 190
            |.||.     |:.||.......|.|........|:.||:...:  |:....: :..|..:.|:.|
  Rat    30 FSELFFMKEPQDATVTRKDPVFLDCQAHGEGPIKVTWLKNGAK--LSENKRIQVLSNGSLYISEA 92

  Fly   191 EKRAWILRIRDVKESDKGWYMC-QINT-DPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTL 253
            |.|..       ::||:|:|.| .:|. ..:.||..:|.:........:|.||:  :.||.....
  Rat    93 EGRRG-------EQSDEGFYQCLAVNKYGAILSQKAHLTLSTISAFEVHPVSTE--VPEGGVARF 148

  Fly   254 KCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSK 318
            .|..:.:|...|||......| |:...:...|.....|.|......:.|.|.|:|:.......|.
  Rat   149 SCKISSTPPAVITWEFNRTAL-PMTMDSRVTALPSGVLQIYDAGPEDAGKYRCVAATHAHKRKSM 212

  Fly   319 RVMLIV--------HFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPGERFV 375
            ...|.:        .:.|.|....|.|.|:|.|.:.|||.:..|||.|..|.:.|...:
  Rat   213 EASLTIVPANETRSFYMPTIIASPQNVTASLHQTVVLECMATGYPKPIISWSRLDHKSI------ 271

  Fly   376 PETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAP------- 433
             :.|.:.......|.|.:|.:|..|.|.|.| .:.|..:..:.:      .|:|.:||
  Rat   272 -DVFNTRVLGNGNLIISDVKLQHAGVYVCRA-TTPGTRNFTVAM------ATLTVLAPPSFVEWP 328

  Fly   434 -------------TVSINTVPVVLVKYNKEQRYGSSQNSNTNPYNFN----------------PG 469
                         ......:|...:.:.|..|...| |.....||..                ..
  Rat   329 ESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRRIHS-NGRIKMYNSKLVINQIIPEDDAIYQCMA 392

  Fly   470 NSQQNTKLQRGKSNSKGSDQSPSGLNNVFVGATSS----------LWNSQDHHSSSSSSSSASSR 524
            .:.|.:.|.|.:.....|:..||...||.....||          |:||....:.|.....|...
  Rat   393 ENSQGSVLSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGL 457

  Fly   525 GRDHHQ------QQHHQQQQQNHGSDH----------GASYRSDGKSPHLTNH 561
            ..:.:|      ..|:........|::          |||..||    |:|.:
  Rat   458 NNEEYQVVLGNDTTHYIIDDLEPDSNYTFYIVAYMPMGASQMSD----HVTQN 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	23/95 (24%)
		IG_like	137..230	CDD:214653	23/95 (24%)
		IG_like	240..324	CDD:214653	20/83 (24%)
		IGc2	247..310	CDD:197706	16/62 (26%)
		Ig	327..419	CDD:299845	26/91 (29%)
		IG_like	343..420	CDD:214653	20/76 (26%)
Prtg	NP_001032740.2	Ig	32..124	CDD:416386	24/100 (24%)
		Ig strand A	32..35	CDD:409353	2/2 (100%)
		Ig strand A'	38..44	CDD:409353	1/5 (20%)
		Ig strand B	48..58	CDD:409353	2/9 (22%)
		Ig strand C	62..68	CDD:409353	2/5 (40%)
		Ig strand C'	70..73	CDD:409353	0/4 (0%)
		Ig strand D	78..83	CDD:409353	0/4 (0%)
		Ig strand E	85..91	CDD:409353	1/5 (20%)
		Ig strand F	103..110	CDD:409353	3/6 (50%)
		Ig strand G	114..124	CDD:409353	2/9 (22%)
		Ig	131..218	CDD:416386	21/89 (24%)
		Ig strand B	146..150	CDD:409353	0/3 (0%)
		Ig strand C	159..163	CDD:409353	2/3 (67%)
		Ig strand E	183..187	CDD:409353	1/3 (33%)
		Ig strand F	197..202	CDD:409353	2/4 (50%)
		Ig strand G	211..214	CDD:409353	1/2 (50%)
		Ig_3	230..302	CDD:404760	25/79 (32%)
		Ig strand B	247..251	CDD:409353	1/3 (33%)
		Ig strand C	260..264	CDD:409353	1/3 (33%)
		Ig strand E	282..286	CDD:409353	1/3 (33%)
		Ig strand F	296..301	CDD:409353	2/4 (50%)
		I-set	322..407	CDD:400151	10/85 (12%)
		Ig strand C	352..357	CDD:409353	0/4 (0%)
		Ig strand C'	359..362	CDD:409353	1/2 (50%)
		Ig strand D	367..371	CDD:409353	0/3 (0%)
		Ig strand E	373..378	CDD:409353	0/4 (0%)
		Ig strand F	387..394	CDD:409353	0/6 (0%)
		Ig strand G	398..407	CDD:409353	2/8 (25%)
		FN3	414..507	CDD:238020	21/97 (22%)
		FN3	512..605	CDD:238020
		fn3	619..694	CDD:394996
		FN3	721..809	CDD:238020
		FN3	816..906	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100