DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Igsf9b

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	98/363 - (26%)
Similarity:	158/363 - (43%)	Gaps:	62/363 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 KDLPKFGELLQNVTVPVSREAVLQCVVDNLQT-----YKIAWLRVDTQTILTIQ-----NHVITK 181
            ::.|:|      ||.......||:|.|.:..|     |.:.|.:......:.|:     .||..:
  Rat    27 REEPEF------VTARAGEGVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPE 85

  Fly   182 NHRMSITHAEKRAWILRIRDVKESDKGWYMC-------QINTDPMKSQVGYLDVVVPPDILDYPT 239
            ....:..| :|.:  ||:..|:..|:|||.|       |.:|....|.| :|.:..||...:.|.
  Rat    86 YAGRASLH-DKAS--LRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWV-HLTINAPPTFTETPP 146

  Fly   240 STDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAY 304
            .. :..:||.::|:.|.|.|:|.|.:||.:||..|  ..:|...|: :|| ||:..|:|.:.|||
  Rat   147 QY-IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL--SASGKYQVS-DGS-LTVTSVSREDRGAY 206

  Fly   305 LCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINY-WMKNDTII 368
            .|.|.: |.........|:|..||.|....:.:...::|:..|.|::||||.::.| |...|..:
  Rat   207 TCRAYS-IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENV 270

  Fly   369 VPGERFVPETFESGYKITMR------LTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTT 427
            .         |::..|:.:|      |.|:.|..:|.|.|.||..||||.:..|.....:.....
  Rat   271 Y---------FQNDLKLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPAR 326

  Fly   428 MTTMAPTVSINT-------------VPVVLVKYNKEQR 452
            :..|.|.:.:..             .|..:||:||:.|
  Rat   327 VLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGR 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	27/109 (25%)
		IG_like	137..230	CDD:214653	27/109 (25%)
		IG_like	240..324	CDD:214653	28/83 (34%)
		IGc2	247..310	CDD:197706	26/62 (42%)
		Ig	327..419	CDD:299845	29/98 (30%)
		IG_like	343..420	CDD:214653	26/83 (31%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	20/76 (26%)
		I-set	139..225	CDD:369462	30/91 (33%)
		Ig	229..321	CDD:386229	28/100 (28%)
		Ig	<353..414	CDD:386229	6/12 (50%)
		Ig	438..502	CDD:319273
		FN3	510..605	CDD:238020
		FN3	621..703	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910