DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Igsf9

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	87/355 - (24%)
Similarity:	140/355 - (39%)	Gaps:	63/355 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 LRIRDVKESDKGWYMCQI--------NTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTL 253
            |:|..::..|:|||.|::        ..|.......:|.|..||...:.|... :.::|...|||
  Rat    93 LQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLV-LEVKELEAVTL 156

  Fly   254 KCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSK 318
            :|.|.|||.|.:||:..|.:   |..|...|......|.|.:|.|.:.|.|.|.||: ...:|:.
  Rat   157 RCVALGSPQPYVTWKFRGQD---LGKGQGQVQVRNGTLWIRRVERGSAGDYTCQASS-TEGSVTH 217

  Fly   319 RVMLIVHFPPMIWI--QNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPGERFVPETFES 381
            ...|:|..||:|.:  .|..|.|  :|:::|.|::||||.::.|....|.|.|    |.....:|
  Rat   218 TTQLLVLGPPVIVVPPNNNTVNA--SQDVSLACRAEAYPANLTYSWFQDRINV----FHISRLQS 276

  Fly   382 GYKITM--RLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSI------- 437
            ..:|.:  .|.:......|.|.|.||..|.......|.....:.....:|.|.|...:
  Rat   277 RVRILVDGSLWLQATQPDDAGHYTCVPSNGFPHPPSASAYLTVLYPAQVTVMPPETPLPIGMRGV 341

  Fly   438 ------NTVPVVLVKYNKEQRYGSSQNSNTNPYNFNPGNSQQNTKLQRGKSNSKGSDQSPSGLNN 496
                  ...|::.|.:.|:                  |.:.|..|.       .|....|.|...
  Rat   342 IRCPVRANPPLLFVTWTKD------------------GQALQLDKF-------PGWSLGPEGSLV 381

  Fly   497 VFVGATSSL--WNSQDHHSSSSSSSSASSR 524
            :.:|...:|  ::...::|..::.||..:|
  Rat   382 IALGNEDALGEYSCTPYNSLGTAGSSPVTR 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	10/40 (25%)
		IG_like	137..230	CDD:214653	10/40 (25%)
		IG_like	240..324	CDD:214653	27/83 (33%)
		IGc2	247..310	CDD:197706	24/62 (39%)
		Ig	327..419	CDD:299845	28/95 (29%)
		IG_like	343..420	CDD:214653	22/78 (28%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	7/16 (44%)
		Ig strand A	136..139	CDD:409353	1/2 (50%)
		IG_like	143..223	CDD:214653	27/84 (32%)
		Ig strand A'	145..148	CDD:409353	0/3 (0%)
		Ig strand B	154..161	CDD:409353	4/6 (67%)
		Ig strand C	167..172	CDD:409353	2/4 (50%)
		Ig strand C'	175..177	CDD:409353	0/4 (0%)
		Ig strand D	183..187	CDD:409353	1/3 (33%)
		Ig strand E	189..193	CDD:409353	1/3 (33%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	2/9 (22%)
		Ig_3	226..305	CDD:404760	26/84 (31%)
		putative Ig strand A	226..230	CDD:409353	2/3 (67%)
		putative Ig strand A'	235..239	CDD:409353	1/3 (33%)
		putative Ig strand B	241..251	CDD:409353	3/9 (33%)
		putative Ig strand C'	267..270	CDD:409353	1/6 (17%)
		putative Ig strand D	279..282	CDD:409353	1/2 (50%)
		putative Ig strand E	284..290	CDD:409353	1/5 (20%)
		putative Ig strand F	297..305	CDD:409353	4/7 (57%)
		putative Ig strand G	310..319	CDD:409353	1/8 (13%)
		Ig	322..407	CDD:416386	15/109 (14%)
		Ig strand A'	324..328	CDD:409353	1/3 (33%)
		Ig strand B	333..347	CDD:409353	0/13 (0%)
		Ig strand C	353..359	CDD:409353	1/5 (20%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	1/2 (50%)
		Ig strand E	378..382	CDD:409353	1/3 (33%)
		Ig strand F	391..399	CDD:409353	0/7 (0%)
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000