DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-theta and Ncam2

DIOPT Version :9

Sequence 1:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_981954.2 Gene:Ncam2 / 288280 RGDID:1303131 Length:837 Species:Rattus norvegicus


Alignment Length:681 Identity:142/681 - (20%)
Similarity:234/681 - (34%) Gaps:163/681 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 RRQRRRAAGKLQRKREMPEISSRLIVATATAAV-------VSIICLSLALPGCAAQESDDEGELH 75
            |.|...|.|:.|....:.||..:|......:..       ..::|...:.|..|.      ..|:
  Rat    92 RCQATDAKGQTQEATVVLEIYQKLTFREVLSPQEFKQGEDAEVVCRVSSSPAPAV------SWLY 150

  Fly    76 HLDQM------------HHQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIREDTVVNAIPEKD 128
            |.:::            ::..|...|.:|:|..:......|.:.:.:..:.|   .:||..|...
  Rat   151 HNEEVTTIPDNRFAVLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDII---VIVNVPPAIV 212

  Fly   129 LPK--FGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRMSITHAE 191
            :|:  |     |.|.....|..|.|.........|:|.|         ...:|.:|.:..:..:.
  Rat   213 MPQKSF-----NATAERGEEMTLTCKASGSPDPAISWFR---------NGKLIEENEKYILKGSN 263

  Fly   192 KRAWILRIRDVKESDKGWYMCQINTDPMKSQ-VGYLDVVVPPDILDYPTSTDMVIREGSNVTLKC 255
            ..   |.:|::...|.|.|:|:......:.| ..:|.|.|.|.||.....|   ..|..:|||.|
  Rat   264 TE---LTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNET---TSENGHVTLIC 322

  Fly   256 AATGSPTPTITWRR--------EGGELIPLPNG-AEAVAYNG-SFLTIAKVNRLNMGAYLCIASN 310
            .|.|.|.|.|||:|        ||.:   .|:| .|....:| |.|.|..|...:.|.|.|.|::
  Rat   323 EAEGEPVPEITWKRAIDGVTFSEGDK---SPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAAS 384

  Fly   311 GIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQN-ITLECQSEAYPKSINYWMKNDTIIVPGERF 374
            .|... .:.:.|.:.:.|. ::.||.:..:...| |.:.|..:|.|.:..:| :.:.:::|.:..
  Rat   385 RIGGH-QRSMHLDIEYAPK-FVSNQTMYYSWEGNPINISCDVKANPPASIHW-RREKLVLPAKNT 446

  Fly   375 VP-ETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLG--------------DTDGAIKLYHIPQ 424
            .. :|...|.|  |.|.|......|||.|.|.|.|.:|              .:...:|:..:.|
  Rat   447 THLKTHSVGRK--MILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPRGVKIIELSQ 509

  Fly   425 TTTMTTMAPTVSINTVPVVLVKYNKEQRYGSSQNSNTNPYNFNPGNSQQNT-KLQRGKSNSKG-- 486
            ||..                :.:||.:.:|...   .:.|..:.......| |:.|    |.|  
  Rat   510 TTAK----------------ISFNKPESHGGVP---IHHYQVDVKEVTSETWKIVR----SHGVQ 551

  Fly   487 -----SDQSPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASSRGRDHHQQQHHQQQQQNHGSDHG 546
                 |...|:....|.|.|.    |.:.....|......:...|:......|.|..........
  Rat   552 TTVVLSSLEPNTTYEVRVAAV----NGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKIS 612

  Fly   547 ASYRSDGKSP---HLTNHDAKSLTDD--------------LDRMQDLKGW------ASRLSPISP 588
            .:.:.||.:|   ::..:.:|...|.              |:.:|...|:      |:||....|
  Rat   613 ITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEP 677

  Fly   589 I--------------------LGLSMILGVG 599
            .                    |||..|:|:|
  Rat   678 TVYEFSMPPKPNIIKDTLFNGLGLGAIIGLG 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 19/93 (20%)
IG_like 137..230 CDD:214653 19/93 (20%)
IG_like 240..324 CDD:214653 30/93 (32%)
IGc2 247..310 CDD:197706 27/72 (38%)
Ig 327..419 CDD:299845 24/107 (22%)
IG_like 343..420 CDD:214653 22/92 (24%)
Ncam2NP_981954.2 IgI_1_NCAM-2 21..113 CDD:409452 7/20 (35%)
Ig strand B 38..42 CDD:409452
Ig strand C 50..54 CDD:409452
Ig strand E 76..80 CDD:409452
Ig strand F 90..95 CDD:409452 1/2 (50%)
Ig strand G 104..107 CDD:409452 0/2 (0%)
IGc2 128..189 CDD:197706 9/66 (14%)
Ig strand B 130..139 CDD:409353 1/8 (13%)
Ig strand C 145..153 CDD:409353 3/13 (23%)
Ig strand C' 156..159 CDD:409353 0/2 (0%)
Ig strand D 162..167 CDD:409353 0/4 (0%)
Ig strand E 168..175 CDD:409353 1/6 (17%)
IgI_1_MuSK 209..298 CDD:409562 21/105 (20%)
Ig strand B 228..232 CDD:409562 1/3 (33%)
Ig strand C 241..245 CDD:409562 1/3 (33%)
Ig strand E 264..268 CDD:409562 1/6 (17%)
Ig strand F 278..283 CDD:409562 2/4 (50%)
Ig strand G 291..294 CDD:409562 1/2 (50%)
Ig 300..397 CDD:416386 34/103 (33%)
Ig strand A 300..305 CDD:409353 2/4 (50%)
Ig strand A' 309..313 CDD:409353 1/6 (17%)
Ig strand B 317..325 CDD:409353 4/7 (57%)
Ig strand C 331..337 CDD:409353 3/5 (60%)
Ig strand C' 340..343 CDD:409353 0/2 (0%)
Ig strand D 353..359 CDD:409353 1/5 (20%)
Ig strand E 362..368 CDD:409353 2/5 (40%)
Ig strand F 376..384 CDD:409353 4/7 (57%)
Ig strand G 387..397 CDD:409353 1/10 (10%)
Ig_3 401..479 CDD:404760 22/81 (27%)
Ig strand B 418..422 CDD:409353 1/3 (33%)
Ig strand C 431..435 CDD:409353 1/4 (25%)
Ig strand E 458..462 CDD:409353 2/3 (67%)
Ig strand F 472..477 CDD:409353 2/4 (50%)
Ig strand G 486..489 CDD:409353 0/2 (0%)
FN3 496..588 CDD:238020 20/118 (17%)
fn3 594..678 CDD:394996 13/83 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12231
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.000

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