DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Dscam4

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	119/550 - (21%)
Similarity:	205/550 - (37%)	Gaps:	156/550 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RRAAGKLQRK-----------REMPEIS----SRLIVATATAAVVSIICLSLALPGCAAQESDDE 71
            :.|.||:...           ||||:|:    |.|||....|.
  Fly   502 QNAIGKVSHSAKVNIYGLPYIREMPKITGISGSDLIVKCPVAG---------------------- 544

  Fly    72 GELHHLDQMH----------------HQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIREDTV 120
               :.:|::|                :.:...||.:.:..:....:....|||.:  :..|.:..
  Fly   545 ---YPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQK--QTSRRNVE 604

  Fly   121 VNA-IPEKDLPKFGELLQNVTVPVSRE---AVLQC-VVDNLQTYKIAWLRVDTQTILTIQNHVIT 180
            :.. :|.|.:|     :|.:| .:.||   |.:.| :::........|.| :.:.::...|.|..
  Fly   605 IQVLVPPKIMP-----IQAMT-NMLREGMRAAISCQILEGDLPVSFRWER-NGKPLIGTGNEVFR 662

  Fly   181 KNHRMSITHAEKRAWILRIRDVKESDKGWYMCQINTDPMKSQVG-------YLDVVVPPDILDYP 238
            :....|.:        |.|..:.....|.|.|      :.|.|.       .|.|.|||..:..|
  Fly   663 RLDEYSAS--------LVIEHISSDHSGNYTC------IASNVAGTERFTVPLTVNVPPKWILEP 713

  Fly   239 TSTDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAY--------NGSFLTIAK 295
              .|...:.|::|.|.|.::|.|||||||::..|   |.|...:...|        ||: :...|
  Fly   714 --KDSSAQAGADVLLHCQSSGYPTPTITWKKAIG---PTPGEYKDFLYEPTVQLFPNGT-IFFKK 772

  Fly   296 VNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINY 360
            :::.:.|.:||.|.|.|...|||.:.|.|:.|.....:.:.:..|..:.:.::|..:. ...|::
  Fly   773 ISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQG-DNPIDF 836

  Fly   361 WMKNDTIIVPGERFVPETFESGYKITMRL----TIYEVDI-----QDFGAYRCVAKNSLGDTDGA 416
            ..|    |...::::.|:.:|.|.|..::    .:.|:.|     ||.|.|.|.|.|:.|..:.:
  Fly   837 KWK----IQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMS 897

  Fly   417 IKLYHIPQTTTMTTMAPTVSINTVPVVLVKYNKEQRYGSSQNSNTNPYNFNPGNSQQNTKLQRGK 481
            |:|.                :..||        ||           |.|... ||||:..||...
  Fly   898 IQLI----------------VQEVP--------EQ-----------PKNLRI-NSQQSRSLQLTW 926

  Fly   482 SNSKGSDQSPSGLNNVFVGATSSLWNSQDH 511
            |.....: ||....:::....|.:|.:.:|
  Fly   927 SQPFAGN-SPIEEYHIYYKQISDIWQNAEH 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	20/103 (19%)
		IG_like	137..230	CDD:214653	20/103 (19%)
		IG_like	240..324	CDD:214653	30/91 (33%)
		IGc2	247..310	CDD:197706	23/70 (33%)
		Ig	327..419	CDD:299845	21/100 (21%)
		IG_like	343..420	CDD:214653	19/85 (22%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548	3/13 (23%)
		Ig strand B	439..443	CDD:409548
		Ig strand C	452..456	CDD:409548
		Ig strand E	482..486	CDD:409548
		Ig strand F	496..501	CDD:409548
		Ig strand G	509..512	CDD:409548	0/2 (0%)
		IgI_5_Dscam	520..607	CDD:409550	18/113 (16%)
		Ig strand B	536..540	CDD:409550	3/3 (100%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	0/3 (0%)
		Ig strand F	586..591	CDD:409550	0/4 (0%)
		Ig strand G	600..603	CDD:409550	1/2 (50%)
		Ig	610..703	CDD:416386	22/113 (19%)
		Ig strand A	611..613	CDD:409353	0/1 (0%)
		Ig strand A'	620..624	CDD:409353	1/4 (25%)
		Ig strand B	627..636	CDD:409353	2/8 (25%)
		Ig strand C	641..648	CDD:409353	1/6 (17%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	1/4 (25%)
		Ig strand E	668..675	CDD:409353	3/14 (21%)
		Ig strand F	682..690	CDD:409353	3/13 (23%)
		Ig strand G	693..702	CDD:409353	0/8 (0%)
		IgI_7_Dscam	706..801	CDD:409546	33/100 (33%)
		Ig strand B	724..728	CDD:409546	2/3 (67%)
		Ig strand C	737..741	CDD:409546	3/3 (100%)
		Ig strand E	766..770	CDD:409546	1/4 (25%)
		Ig strand F	780..785	CDD:409546	2/4 (50%)
		Ig strand G	794..797	CDD:409546	2/2 (100%)
		Ig	818..904	CDD:416386	20/106 (19%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	1/9 (11%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	2/5 (40%)
		putative Ig strand F	881..889	CDD:409353	4/7 (57%)
		putative Ig strand G	892..902	CDD:409353	3/25 (12%)
		FN3	906..999	CDD:238020	16/70 (23%)
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810