Protein Alignment DIP-theta and NEGR1

DIOPT Version :10

• Sequence 1: NP_723103.1
• Gene: DIP-theta / 33795
• FlyBaseID: FBgn0051646
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 88/288 - (30%)
• Similarity: 138/288 - (47%)
• Gaps: 24/288 - (8%)

  Fly   136 LQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRMSITHAEKRAWILRIR 200
            :.|:.|.....|||:|.::: ...|.|||  :..:|:.......:.:.|:||:...||.:.|:|:
Human    45 VDNMMVRKGDTAVLRCYLED-GASKGAWL--NRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQ 106

  Fly   201 DVKESDKGWYMCQINTD--PMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTLKCAATGSPTP 263
            :|..:|.|.|.|.:.|.  |...|| :|.|.|||.|  |..|.||.:.||:||||.|.|||.|.|
Human   107 NVDVTDDGPYTCSVQTQHTPRTMQV-HLTVQVPPKI--YDISNDMTVNEGTNVTLTCLATGKPEP 168

  Fly   264 TITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPP 328
            :|:||.......|..        ||.:|.|..:.|...|.|.|.|.|.:.....::|.::|:|.|
Human   169 SISWRHISPSAKPFE--------NGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAP 225

  Fly   329 MIWIQNQLVGAALT--QNITLECQSEAYPKSINYWMKNDTIIVPGERFVPETFESGYKITMRLTI 391
            .|   .::....:|  ::..:.|:....|.....|.|.:..:..|::.:   ....:.....||:
Human   226 TI---QEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGI---IIQNFSTRSILTV 284

  Fly   392 YEVDIQDFGAYRCVAKNSLGDTDGAIKL 419
            ..|..:.||.|.|||.|.||.|:.::.|
Human   285 TNVTQEHFGNYTCVAANKLGTTNASLPL 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	IG_like	137..230	CDD:214653	29/94 (31%)
		Ig strand B	147..151	CDD:409353	3/3 (100%)
		Ig strand C	160..164	CDD:409353	2/3 (67%)
		Ig strand E	195..199	CDD:409353	1/3 (33%)
		Ig strand F	209..214	CDD:409353	2/4 (50%)
		Ig strand G	221..224	CDD:409353	1/2 (50%)
		Ig	232..324	CDD:472250	33/91 (36%)
		Ig strand B	251..255	CDD:409275	3/3 (100%)
		Ig strand C	264..268	CDD:409275	1/3 (33%)
		Ig strand E	289..293	CDD:409275	1/3 (33%)
		Ig strand F	303..308	CDD:409275	2/4 (50%)
		Ig strand G	317..320	CDD:409275	0/2 (0%)
		Ig_3	327..408	CDD:464046	17/82 (21%)
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	28/91 (31%)
		Ig strand B	56..60	CDD:409353	3/3 (100%)
		Ig strand C	68..72	CDD:409353	2/3 (67%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	0/2 (0%)
		Ig_3	138..207	CDD:464046	32/78 (41%)
		IG_like	231..312	CDD:214653	19/83 (23%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	0/3 (0%)
		Ig strand E	280..284	CDD:409353	1/3 (33%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)