DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Lrit1

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	392	Identity:	88/392 - (22%)
Similarity:	154/392 - (39%)	Gaps:	107/392 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 HHL-----AEMQNKDEL-LEDIREDTVVNAIPEKDLPKFGELLQNVT-VPVSREAVLQCVVDNLQ 157
            :||     |.:::..:| |.|::.:. ::.:|    |:....|:|:| :.:|...:::...:.|.
  Rat   117 NHLVTFPWAALKDTPQLQLLDLQANR-LSTLP----PEAVHFLENLTFLDLSNNQLMRLPEELLD 176

  Fly   158 TYKIAWLRVDTQTILTIQNHVITKNHRMSITHAEKRAWI--LRIRDVKESDKGW------YMCQI 214
            |    |..:.|...|:      ::..|: :...:...|:  .|:.|:.....||      ...::
  Rat   177 T----WAHLKTGPYLS------SRRTRL-VLGLQDNPWVCDCRLYDLVHLLDGWASNLIFIEARL 230

  Fly   215 NTDPMKSQVGY------LDVVVPPDILDYPTSTDMVIREGSNVTLKCAATGSPTPTITWRREGGE 273
            .....:|..|.      |.....|::  .|..|.::...||.|.|:|.|||.|.|.::|||..|.
  Rat   231 RCGSPRSLAGVAFSQLELRKCQSPEL--RPGVTSIISPLGSTVLLRCGATGIPGPEMSWRRANGR 293

  Fly   274 LIPLPNGA--EAVAYNGS---FLTIAKVNRLNMGAYLCIASN--GIPPTVSKRVMLIV------- 324
              || ||.  :.|:.:||   .|.:..|:..:.|.|:|.|.|  |...|:   :.|||
  Rat   294 --PL-NGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETL---ISLIVTEPQTST 352

  Fly   325 ---HFPPMIWIQ-----------NQLVG---------AALTQNITLECQSEAYPKSINYWMKNDT 366
               ..|..:|.:           |:||.         .||....::....|..|      ::|..
  Rat   353 EYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVPSIKEELP------LQNFQ 411

  Fly   367 IIVPGERFVPETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKL-YHIPQTTTMTT 430
            :.|||| |..|..|  ::.|..:...:|               :|||..::.| :..||....|.
  Rat   412 MDVPGE-FSREPSE--HQETQMVRSLKV---------------VGDTYHSVSLVWKAPQAGNTTA 458

  Fly   431 MA 432
            .:
  Rat   459 FS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	17/107 (16%)
		IG_like	137..230	CDD:214653	17/107 (16%)
		IG_like	240..324	CDD:214653	32/90 (36%)
		IGc2	247..310	CDD:197706	27/67 (40%)
		Ig	327..419	CDD:299845	22/111 (20%)
		IG_like	343..420	CDD:214653	16/77 (21%)
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566	6/26 (23%)
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378	3/14 (21%)
		LRR 3	108..128		3/10 (30%)
		LRR_8	131..>176	CDD:290566	9/49 (18%)
		LRR_4	131..172	CDD:289563	9/45 (20%)
		LRR 4	132..153		5/25 (20%)
		leucine-rich repeat	133..156	CDD:275378	6/27 (22%)
		LRR 5	156..177		4/20 (20%)
		leucine-rich repeat	157..180	CDD:275378	5/26 (19%)
		leucine-rich repeat	181..205	CDD:275378	4/30 (13%)
		TPKR_C2	201..>240	CDD:301599	6/38 (16%)
		Ig	257..345	CDD:299845	33/93 (35%)
		IG_like	267..345	CDD:214653	31/83 (37%)
		FN3	431..501	CDD:214495	8/45 (18%)
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900