DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Ptprq

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	374	Identity:	72/374 - (19%)
Similarity:	129/374 - (34%)	Gaps:	112/374 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 MQNKDELLEDIREDTVVNAIPEKD----LPKFGELLQNVTVPVSREAVLQCVVD--NLQTYKIAW 163
            ::.|.:.|...|...|:....:.:    :...||.|...||.:.....| |::.  .|.|...|:
Mouse  1866 LKPKKQYLFKFRATNVMGQFTDSEYSDPIKTLGEGLSERTVEIILSVTL-CILSIILLGTAIFAF 1929

  Fly   164 LRV-------------DTQTI--------------LTIQNHVITK--NHRMSITHAEKRAWILRI 199
            .|:             |.:.|              |.:::..:|:  ::|.||....|::::..:
Mouse  1930 ARIRQKQKEGGTYSPRDAEIIDTKFKLDQLITVADLELKDERLTRLLSYRKSIKPVSKKSFLQHV 1994

  Fly   200 RDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTLKCAATGSPTPT 264
            .:         :|..|.  :|.|..:.::   |..|...:|||                    ..
Mouse  1995 EE---------LCTNNN--LKFQEEFSEL---PKFLQDLSSTD--------------------AD 2025

  Fly   265 ITWRREGGELIPLPNGAEAVAYNGSFLTIAK---------VNRLNMGAYLC----IASNG-IPPT 315
            :.|.|....   .||   ...||.:.:.:..         :|...:..|||    ||:.| :|.|
Mouse  2026 LPWNRAKNR---FPN---IKPYNNNRVKLIADVSIPGSDYINASYVSGYLCPNEFIATQGPLPGT 2084

  Fly   316 VSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMK-NDTIIVPGERFVPETF 379
            |.       .|..|:|.........|||     |..:...:...||.: |..:.|.|:..:.:..
Mouse  2085 VG-------DFWRMVWETRAKTLVMLTQ-----CFEKGRIRCHQYWPEDNKPVTVFGDILITKLM 2137

  Fly   380 ESGYKITMRLTIYEVDIQDFGAYRCVAK-NSLGDTDGAIKLYHIPQTTT 427
            |.   |.:..||.::.|:..|....|.: |..|..:     :.:|:.||
Mouse  2138 ED---IQIDWTIRDLKIERHGDCMTVRQCNFTGWPE-----HGVPENTT 2178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	20/123 (16%)
		IG_like	137..230	CDD:214653	20/123 (16%)
		IG_like	240..324	CDD:214653	19/97 (20%)
		IGc2	247..310	CDD:197706	12/75 (16%)
		Ig	327..419	CDD:299845	20/93 (22%)
		IG_like	343..420	CDD:214653	16/78 (21%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020
		FN3	308..393	CDD:238020
		fn3	399..>441	CDD:365830
		FN3	570..654	CDD:238020
		fn3	668..744	CDD:365830
		FN3	762..850	CDD:238020
		fn3	857..934	CDD:365830
		FN3	951..1049	CDD:238020
		FN3	1056..1137	CDD:238020
		FN3	1152..1233	CDD:238020
		FN3	1247..1337	CDD:238020
		FN3	1342..1421	CDD:238020
		FN3	1432..1535	CDD:238020
		FN3	1542..1638	CDD:238020
		FN3	1645..1734	CDD:238020
		UP_III_II	1759..1928	CDD:297589	13/62 (21%)
		R-PTPc-Q	2033..2256	CDD:350464	38/172 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900