DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DIP-theta and SDK1

DIOPT Version :9

Sequence 1:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:495 Identity:107/495 - (21%)
Similarity:177/495 - (35%) Gaps:133/495 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RRRAAGKLQRKREMP--------EISSRLIVATATAAVVSIICLS--------------LALPG- 62
            |.|....||||.|:.        :...|..|:...||:::::.::              ..:|. 
Human   172 RNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSN 236

  Fly    63 -----------CAAQESDDEGELHHLDQMHHQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIR 116
                       ..|..:.|.| .:::..::.::     ||::....|  ||:       :..|: 
Human   237 RIAITLENQLVILATTTSDAG-AYYVQAVNEKN-----GENKTSPFI--HLS-------IARDV- 285

  Fly   117 EDTVVNAIPEKDLPKFGELLQNVTVPV--------SREAVLQCVVD--NLQTYKIAWLRVDTQTI 171
                  ..||...|       .:.||.        |.|..|:|:..  .::...:.|        
Human   286 ------GTPETMAP-------TIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW-------- 329

  Fly   172 LTIQNHVITKNHRMSIT---HAEKRAWILRIRDVKESDKGWYMCQINT-----DPMKSQVGYLDV 228
                     |.:.:.||   |:..|.  |.|.:...:|.|.|:|:...     :|.:: ..:|.:
Human   330 ---------KRNGVRITSGLHSFGRR--LTISNPTSADTGPYVCEAALPGSAFEPARA-TAFLFI 382

  Fly   229 VVPPDILDYPTSTDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTI 293
            :.||.....|.|......| ..|.:.|.|.|.|.||:.|.::...:..|.|....|..:|. |.|
Human   383 IEPPYFTAEPESRISAEVE-ETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG-LRI 445

  Fly   294 AKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNIT--LECQSEAYPK 356
            .|:...:.|.:.|.|||......:...:.:.:..|:  ...:.|...:|..:|  |.|:....||
Human   446 QKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPV--FTQRPVDTTVTDGMTAILRCEVSGAPK 508

  Fly   357 SINYWMKNDTIIVPGERFVPE--TFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKL 419
            ....|.:.:.|:..|...:|.  ..|||     .|.|..|.|||.|.|.|.|.|:.|..:.:..|
Human   509 PAITWKRENHILASGSVRIPRFMLLESG-----GLQIAPVFIQDAGNYTCYAANTEGSLNASATL 568

  Fly   420 --------YHIPQT------TTMT-----TMAPTVSINTV 440
                    .|.|:.      ||.|     |..|.||:..|
Human   569 TVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYV 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 20/110 (18%)
IG_like 137..230 CDD:214653 20/110 (18%)
IG_like 240..324 CDD:214653 22/83 (27%)
IGc2 247..310 CDD:197706 19/62 (31%)
Ig 327..419 CDD:299845 27/95 (28%)
IG_like 343..420 CDD:214653 25/88 (28%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352 7/15 (47%)
Ig 122..176 CDD:143165 2/3 (67%)
Ig 219..265 CDD:299845 4/46 (9%)
IGc2 312..364 CDD:197706 14/70 (20%)
I-set 386..475 CDD:254352 24/90 (27%)
Ig 404..472 CDD:143165 20/68 (29%)
I-set 480..570 CDD:254352 28/96 (29%)
Ig 494..570 CDD:299845 25/80 (31%)
I-set 575..664 CDD:254352 10/34 (29%)
Ig 580..664 CDD:299845 9/29 (31%)
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.