DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-theta and DSCAM

DIOPT Version :9

Sequence 1:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:634 Identity:146/634 - (23%)
Similarity:217/634 - (34%) Gaps:161/634 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 AAVVSIIC--LSLALPGCAAQESDD---EGELHHLDQMHHQHQDFI----IGESEEHDHIAHHLA 103
            |..||::|  ....||.......||   :|..|.:.||.....:.:    |..|:..|...:...
Human   421 AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485

  Fly   104 EMQNKDELLEDIREDTVVNAI-PEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVD 167
            ...:...:|...|    :|.. |....|     ::|:|....|:..:.|.|.....|.|.|.:  
Human   486 ANNSAGVVLYQAR----INVRGPASIRP-----MKNITAIAGRDTYIHCRVIGYPYYSIKWYK-- 539

  Fly   168 TQTILTIQNHVITKNHRMSITHAEKRAWILRIRDV-KESDKGWYMCQINTDPM--KSQVGYLDVV 229
                   .::::..|||..   |.:....|::.|| ||.|:|.|.|.:...|.  .||..::.|.
Human   540 -------NSNLLPFNHRQV---AFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK 594

  Fly   230 VPP------------------------------------------------DILDYPTS------ 240
            |||                                                |.:|:.:|      
Human   595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNL 659

  Fly   241 ----------------------TDMVIR---------------EGSNVTLKCAATGSPTPTITWR 268
                                  :.:::|               .|..|.|.|:|.|.|.|||.|:
Human   660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724

  Fly   269 REGGELIP-----LPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPP 328
            ...|..:|     ..||...|..|||.| |..|...:.|.|||..||.:...|||.:.|.|..|.
Human   725 FSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA 788

  Fly   329 MIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPG-ERFVPETFESGYKITMRLTIY 392
            ||........|...|...:.|.:......|..|.|.|.||.|. .|::..|.|.|.::...|.|.
Human   789 MITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 853

  Fly   393 EVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVP--VVLVKYNKEQRYGS 455
            ....:|.|.:.|.|.||.|:..|.|:|     |.......|.:.|..|.  .:.:::.    .|.
Human   854 PTVREDSGFFSCHAINSYGEDRGIIQL-----TVQEPPDPPEIEIKDVKARTITLRWT----MGF 909

  Fly   456 SQNSNTNPYNFNPGN------SQQNTKLQRGKSNSKG-SDQSPSGLNNVFVGATSSLWNSQDHHS 513
            ..||....|:....|      |.|.||....:.||.. .|..||...::.:.|.:.:..|:   .
Human   910 DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE---P 971

  Fly   514 SSSSSSSASSRGRDHHQQQHHQQQQQNHGSDHGASYRSDGKSP--HLTN 560
            |:..:.:|.....|...|:.|.:...:.      |.|...|:|  ||.|
Human   972 SNELTITADEAAPDGPPQEVHLEPISSQ------SIRVTWKAPKKHLQN 1014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 25/95 (26%)
IG_like 137..230 CDD:214653 25/95 (26%)
IG_like 240..324 CDD:214653 34/131 (26%)
IGc2 247..310 CDD:197706 26/67 (39%)
Ig 327..419 CDD:299845 28/92 (30%)
IG_like 343..420 CDD:214653 24/77 (31%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352
I-set 315..385 CDD:333254
Ig_3 407..488 CDD:316449 15/66 (23%)
IGc2 518..575 CDD:197706 18/68 (26%)
I-set 596..686 CDD:333254 5/89 (6%)
Ig_DSCAM 707..784 CDD:143211 31/77 (40%)
Ig 802..889 CDD:325142 26/91 (29%)
FN3 885..978 CDD:238020 20/99 (20%)
FN3 986..1083 CDD:238020 9/35 (26%)
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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