DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and rig-5

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001251131.1	Gene:	rig-5 / 172791	WormBaseID:	WBGene00004372	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	126/413 - (30%)
Similarity:	195/413 - (47%)	Gaps:	74/413 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 CVVDNLQTYKIAWLRVDT-QTILTIQNHVITKNH------RMSITHAEKRAWILRIRDVKESDKG 208
            |:|::|.::.:|:::.|: ..:|:....|..:.:      |:...|.|   |:|.|::|:|||:|
Worm   106 CIVNDLGSHMVAFVKADSPPRLLSFDEKVFRRRNKYELKPRIGDLHNE---WVLTIKNVQESDRG 167

  Fly   209 WYMCQINTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTLKCAATGSPTPTITWRREGGE 273
            .|.|||||:|:....|.|||.||| ::...|...:.:|||:||:|.|.|.|:||||:.|||:..:
Worm   168 NYSCQINTEPITLSTGELDVKVPP-VVSRSTPAAVEVREGNNVSLTCKADGNPTPTVIWRRQDRQ 231

  Fly   274 LIPLPNGAE---AVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMIWIQNQ 335
            :|.. |||.   |..::|..|.:.||:|.:|..|||:|||||||..|..|.|:|.|||::..|::
Worm   232 IIRY-NGATGFGASVFHGPVLHLTKVSRKHMSEYLCVASNGIPPDESWTVKLLVTFPPLVQAQSE 295

  Fly   336 LVGAALTQNITLECQSEAYPKSINYWMKN-DTIIVPGERFVPETFESGYKITMRLTIYEVDIQDF 399
            .|.|::.....:.|.:||:|:....|.|: :.:.......:..|....|.....|.|..|....|
Worm   296 TVQASVGSMARMVCTTEAWPRPEMGWEKDGEPVYESNNVAMTHTVSGQYHSVHILEIRNVQSSHF 360

  Fly   400 GAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVPVVLVKYNKEQRYGSSQNSNTNPY 464
            |.|||||||..|       ::|           ..|::|.:               |.|..||.
Worm   361 GVYRCVAKNDNG-------IHH-----------SQVTLNQI---------------SHNHFTNS- 391

  Fly   465 NFNPGNSQQNTKLQRGKSNSKGSDQSPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASSRGRDHH 529
            |..|    :.:.:.||.|....:|:....|.|            |.:.|....|.|.
Worm   392 NLIP----EGSGMPRGYSEDDEADEEEDNLEN------------QKNDSEEEDSQSP-------- 432

  Fly   530 QQQHHQQQQQNHGSDHGASYRSD 552
            .|.....|.:.|.|.:..:.||:
Worm   433 PQLEFYSQARRHESRNAPTTRSE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	29/85 (34%)
		IG_like	137..230	CDD:214653	29/85 (34%)
		IG_like	240..324	CDD:214653	40/86 (47%)
		IGc2	247..310	CDD:197706	30/65 (46%)
		Ig	327..419	CDD:299845	26/92 (28%)
		IG_like	343..420	CDD:214653	21/77 (27%)
rig-5	NP_001251131.1	IG_like	92..189	CDD:214653	29/85 (34%)
		Ig_3	191..270	CDD:372822	33/80 (41%)
		IG	294..380	CDD:214652	25/103 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I6913
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I2513
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm14489
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100