DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-theta and Dscam

DIOPT Version :9

Sequence 1:NP_723103.1 Gene:DIP-theta / 33795 FlyBaseID:FBgn0051646 Length:606 Species:Drosophila melanogaster
Sequence 2:XP_038943864.1 Gene:Dscam / 171119 RGDID:619992 Length:2034 Species:Rattus norvegicus


Alignment Length:634 Identity:146/634 - (23%)
Similarity:216/634 - (34%) Gaps:161/634 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 AAVVSIIC--LSLALPGCAAQESDD---EGELHHLDQMHHQHQDFI----IGESEEHDHIAHHLA 103
            |..||::|  ....||.......||   :|..|.:.||.....:.:    |..|:..|...:...
  Rat   421 AEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485

  Fly   104 EMQNKDELLEDIREDTVVNAI-PEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVD 167
            ...:...:|...|    :|.. |....|     ::|:|....|:..:.|.|.....|.|.|.:  
  Rat   486 ANNSAGVVLYQAR----INVRGPASIRP-----MKNITAIAGRDTYIHCRVIGYPYYSIKWYK-- 539

  Fly   168 TQTILTIQNHVITKNHRMSITHAEKRAWILRIRDV-KESDKGWYMCQINTDPM--KSQVGYLDVV 229
                   ..:::..|||..   |.:....|::.|| ||.|:|.|.|.:...|.  .||..::.|.
  Rat   540 -------NANLLPFNHRQV---AFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK 594

  Fly   230 VPP------------------------------------------------DILDYPTS------ 240
            |||                                                |.:|:.:|      
  Rat   595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNL 659

  Fly   241 ----------------------TDMVIR---------------EGSNVTLKCAATGSPTPTITWR 268
                                  :.:::|               .|..|.|.|:|.|.|.|||.|:
  Rat   660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724

  Fly   269 REGGELIP-----LPNGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPP 328
            ...|..:|     ..||...|..|||.| |..|...:.|.|||..||.:...|||.:.|.|..|.
  Rat   725 FSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA 788

  Fly   329 MIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPG-ERFVPETFESGYKITMRLTIY 392
            ||........|...|...:.|.:......|..|.|.|.||.|. .|::..|.|.|.::...|.|.
  Rat   789 MITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 853

  Fly   393 EVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVP--VVLVKYNKEQRYGS 455
            ....:|.|.:.|.|.||.|:..|.|:|     |.......|.:.|..|.  .:.:::.    .|.
  Rat   854 PTVREDSGFFSCHAINSYGEDRGIIQL-----TVQEPPDPPEIEIKDVKARTITLRWT----MGF 909

  Fly   456 SQNSNTNPYNFNPGN------SQQNTKLQRGKSNSKG-SDQSPSGLNNVFVGATSSLWNSQDHHS 513
            ..||....|:....|      |.|.||....:.||.. .|..||...::.:.|.:.:..|:   .
  Rat   910 DGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE---P 971

  Fly   514 SSSSSSSASSRGRDHHQQQHHQQQQQNHGSDHGASYRSDGKSP--HLTN 560
            |:..:.:|.....|...|:.|.:...:.      |.|...|:|  ||.|
  Rat   972 SNEITITADEAAPDGPPQEVHLEPTSSQ------SIRVTWKAPKKHLQN 1014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-thetaNP_723103.1 Ig 137..230 CDD:299845 25/95 (26%)
IG_like 137..230 CDD:214653 25/95 (26%)
IG_like 240..324 CDD:214653 34/131 (26%)
IGc2 247..310 CDD:197706 26/67 (39%)
Ig 327..419 CDD:299845 28/92 (30%)
IG_like 343..420 CDD:214653 24/77 (31%)
DscamXP_038943864.1 Ig 26..121 CDD:416386
Ig strand A' 33..37 CDD:409353
Ig strand B 40..49 CDD:409353
Ig strand C 55..61 CDD:409353
Ig strand C' 63..66 CDD:409353
Ig strand D 72..75 CDD:409353
Ig strand E 80..85 CDD:409353
Ig strand F 98..106 CDD:409353
Ig strand G 109..121 CDD:409353
Ig 125..210 CDD:416386
Ig strand A 126..130 CDD:409353
Ig strand A' 132..136 CDD:409353
Ig strand B 139..149 CDD:409353
Ig strand C 157..163 CDD:409353
Ig strand C' 164..167 CDD:409353
Ig strand E 179..185 CDD:409353
Ig strand F 191..201 CDD:409353
IGc2 239..300 CDD:197706
Ig strand B 242..246 CDD:409353
Ig strand C 255..259 CDD:409353
Ig strand F 290..295 CDD:409353
Ig 313..395 CDD:416386
Ig strand A 314..319 CDD:409353
Ig strand A' 322..326 CDD:409353
Ig strand B 329..339 CDD:409353
Ig strand C 344..350 CDD:409353
Ig strand C' 351..354 CDD:409353
Ig strand E 368..374 CDD:409353
Ig strand F 381..389 CDD:409353
Ig 406..501 CDD:416386 17/83 (20%)
Ig strand A 406..409 CDD:409353
Ig strand A' 415..419 CDD:409353
Ig strand B 422..431 CDD:409353 3/8 (38%)
Ig strand C 436..442 CDD:409353 1/5 (20%)
Ig strand C' 444..447 CDD:409353 2/2 (100%)
Ig strand D 452..460 CDD:409353 3/7 (43%)
Ig strand E 464..473 CDD:409353 1/8 (13%)
Ig strand F 480..488 CDD:409353 0/7 (0%)
Ig strand G 491..501 CDD:409353 2/13 (15%)
Ig 504..593 CDD:416386 26/105 (25%)
Ig strand A 505..507 CDD:409353 0/1 (0%)
Ig strand A' 512..516 CDD:409353 2/3 (67%)
Ig strand B 519..526 CDD:409353 1/6 (17%)
Ig strand C 533..539 CDD:409353 3/5 (60%)
Ig strand C' 540..542 CDD:409353 0/1 (0%)
Ig strand D 549..553 CDD:409353 1/6 (17%)
Ig strand E 557..563 CDD:409353 1/5 (20%)
Ig strand F 571..579 CDD:409353 3/7 (43%)
Ig strand G 583..593 CDD:409353 2/9 (22%)
Ig 596..686 CDD:416386 5/89 (6%)
Ig strand A 597..599 CDD:409353 1/1 (100%)
Ig strand B 611..620 CDD:409353 0/8 (0%)
Ig strand C 625..632 CDD:409353 0/6 (0%)
Ig strand C' 634..636 CDD:409353 0/1 (0%)
Ig strand D 643..648 CDD:409353 1/4 (25%)
Ig strand E 651..658 CDD:409353 1/6 (17%)
Ig strand F 665..673 CDD:409353 0/7 (0%)
Ig strand G 676..685 CDD:409353 0/8 (0%)
Ig_DSCAM 689..784 CDD:409397 32/95 (34%)
Ig strand B 707..711 CDD:409397 2/3 (67%)
Ig strand C 720..724 CDD:409397 2/3 (67%)
Ig strand E 749..753 CDD:409397 3/4 (75%)
Ig strand F 763..768 CDD:409397 3/4 (75%)
Ig strand G 777..780 CDD:409397 2/2 (100%)
Ig_DSCAM 785..884 CDD:409398 30/103 (29%)
Ig strand B 805..809 CDD:409398 0/3 (0%)
Ig strand C 818..822 CDD:409398 1/3 (33%)
Ig strand E 848..852 CDD:409398 1/3 (33%)
Ig strand F 862..867 CDD:409398 1/4 (25%)
Ig strand G 875..878 CDD:409398 1/2 (50%)
FN3 885..978 CDD:238020 20/99 (20%)
FN3 986..1083 CDD:238020 9/35 (26%)
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig_3 1287..1363 CDD:404760
Ig strand B 1303..1307 CDD:409353
Ig strand C 1316..1320 CDD:409353
Ig strand E 1342..1346 CDD:409353
Ig strand F 1356..1361 CDD:409353
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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