DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-theta and CHL1

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_006605.2	Gene:	CHL1 / 10752	HGNCID:	1939	Length:	1224	Species:	Homo sapiens

Alignment Length:	679	Identity:	134/679 - (19%)
Similarity:	216/679 - (31%)	Gaps:	228/679 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 QMHHQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIRED-----------TVVNAIPEK----- 127
            ::.|..||..:..|::.|   .:.|.::.||.     |.|           |:|..:|.|
Human   170 ELEHIEQDERVYMSQKGD---LYFANVEEKDS-----RNDYCCFAAFPRLRTIVQKMPMKLTVNS 226

  Fly   128 ----------------------DLPKFGELL--------QNVTVPVSREAVLQCVVDNLQTYKIA 162
                                  ..||.  ||        .::|:......:|:|..:.|.|.::.
Human   227 LKHANDSSSSTEIGSKANSIKQRKPKL--LLPPTESGSESSITILKGEILLLECFAEGLPTPQVD 289

  Fly   163 WLRVDTQTILTIQNHVITKNHRMSITHAEKRAWILRIRDVKESDKGWYMCQINTDPMKSQVGYLD 227
            |.::...         :.|.....    |.....|:|.:|...|||.|.|.. ::.:.:......
Human   290 WNKIGGD---------LPKGRETK----ENYGKTLKIENVSYQDKGNYRCTA-SNFLGTATHDFH 340

  Fly   228 VVV--PPDILDYPTSTDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSF 290
            |:|  ||.....|.|.  |...|||..|.|.|.|.|.|||.||..|..:...|...:.|......
Human   341 VIVEEPPRWTKKPQSA--VYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREIS 403

  Fly   291 LTIAKVNRLNMGAYLCIASNGIPPTVSKRVMLIVHFPPMI------------------------- 330
            .|..:.|  :...|.|.|||.....::...:.:|...|:|
Human   404 FTNLQPN--HTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFAS 466

  Fly   331 --------------------------------------------WIQNQLVGAALTQN------- 344
                                                        |::|.:...|:|.|
Human   467 PEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNAT 531

  Fly   345 ----------------ITLECQSEA---YPKSINY-WMKNDTIIVPGERFVPETFESGYKIT--M 387
                            :.|.|:|:.   ...|:.. |.|:      ||.|.....|.|..|.  .
Human   532 KLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD------GEAFEINGTEDGRIIIDGA 590

  Fly   388 RLTIYEVDIQDFGAYRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVPVVLVKYNKEQR 452
            .|||..|.::|.|.|.|.|..:|   |.|.   .|.|.|.:....|..:::    :..:.|:..|
Human   591 NLTISNVTLEDQGIYCCSAHTAL---DSAA---DITQVTVLDVPDPPENLH----LSERQNRSVR 645

  Fly   453 Y----GSSQNSNTNPY-------NFNPGNSQQNTKLQRGKSNSKGSDQSPSGLNNVFVGATSSLW 506
            .    |:..|||.:.|       ...||..::.|::| ||..:.....:|.......|.|.:.:.
Human   646 LTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQ-GKKTTVILPLAPFVRYQFRVIAVNEVG 709

  Fly   507 NSQ-----DHHSSSSSSSSASSRGRDHHQQQHHQ-------------QQQQNHGSDHGASYRSDG 553
            .||     |||   .:..:|..|...:.:.|..|             .:|...|.::..:::..|
Human   710 RSQPSQPSDHH---ETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQG 771

  Fly   554 -----KSPHLTNHDAKSLTDDLDRMQDLK 577
                 :...:|||..:.:|..:....|:|
Human   772 APVEWEEETVTNHTLRVMTPAVYAPYDVK 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	17/92 (18%)
		IG_like	137..230	CDD:214653	17/92 (18%)
		IG_like	240..324	CDD:214653	25/83 (30%)
		IGc2	247..310	CDD:197706	21/62 (34%)
		Ig	327..419	CDD:299845	31/189 (16%)
		IG_like	343..420	CDD:214653	25/105 (24%)
CHL1	NP_006605.2	Ig	55..126	CDD:299845
		Ig2_L1-CAM_like	129..223	CDD:143253	14/60 (23%)
		IG_like	140..224	CDD:214653	14/61 (23%)
		IG_like	264..343	CDD:214653	17/92 (18%)
		Ig3_L1-CAM_like	274..344	CDD:143208	16/83 (19%)
		IG_like	353..434	CDD:214653	26/84 (31%)
		Ig4_L1-NrCAM_like	361..435	CDD:143179	23/75 (31%)
		IG_like	447..525	CDD:214653	4/77 (5%)
		Ig	457..525	CDD:299845	4/67 (6%)
		IG_like	548..624	CDD:214653	26/87 (30%)
		Ig	548..616	CDD:143165	23/76 (30%)
		DGEA	571..574		1/8 (13%)
		FN3	628..717	CDD:238020	19/93 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..732		7/25 (28%)
		fn3	731..811	CDD:278470	11/70 (16%)
		FN3	834..927	CDD:238020
		FN3	932..1027	CDD:238020
		Bravo_FIGEY	1120..1205	CDD:290593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1179
		FIG[AQ]Y	1197..1201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100