DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Kirrel2

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_038957463.1	Gene:	Kirrel2 / 100359836	RGDID:	1308456	Length:	711	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	121/636 - (19%)
Similarity:	208/636 - (32%)	Gaps:	196/636 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PKFGELLQNVTVPVSREAVLQCVVDNLQTYK--IAWLRVDTQTILTIQNHVITKNHRMSITHAEK 192
            |.|.:..:::.|.:.:||.|.|.   |..|:  :.|    |:..|.:              ..|:
  Rat    32 PHFLQQPEDMVVLLGQEARLPCA---LGAYRGLVQW----TKDGLAL--------------GGER 75

  Fly   193 ------RAWI----------LRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPD---ILDYP 238
                  |.||          |.|:.|:..|:..|.||.:...::|:...|.|:|||:   :|..|
  Rat    76 DLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGP 140

  Fly   239 TSTDMVIREGSNVTLKCAATGSPTPTITWRREGGEL-------IPLPNGAEAVAYNGSFLTIAKV 296
             |..:|.....|:|.:......|.|.:.|.|:|..|       |.|.:.|.....|..|||.:..
  Rat   141 -SVSLVAGVPGNLTCRSRGDARPAPELLWFRDGIRLDGTSFHQITLRDKATGTVENTLFLTPSSQ 204

  Fly   297 NRLNMGAYL-CIA-SNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSIN 359
            :.   ||.| |.| |..:|......|.|.:.:|||:.:..:...|...:.:|..||:.|.|....
  Rat   205 DD---GATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTAQEGEKVTFLCQATAQPPVTG 266

  Fly   360 Y-WMKNDTIIVPGER-----------FVPETFE--------SGYKITMRLTIY-----------E 393
            | |.|..:.:: |.|           |:.|...        |..:.|....:|           .
  Rat   267 YRWAKGGSPVL-GARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKPVS 330

  Fly   394 VDIQDFGAYRCVAKNS---------LG-----DTDGAIKLYHI-------------PQTT----- 426
            ||:....::.||.:.:         ||     .:...::|..:             |:.|
  Rat   331 VDVGKDASFSCVWRGNPLPRISWTRLGGSQVLSSGPTLRLPSVALEDAGDYVCRAEPRRTGVGGG 395

  Fly   427 ----TMTTMAPTV--SINTVPVVL------------------VKYNKEQRY-------------- 453
                .:|..||.|  :::..|..|                  |.::.::.:
  Rat   396 TAQARLTVNAPPVVTALHPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAF 460

  Fly   454 --------------------GSSQNSNTNPYNFNPGN--SQQNTKLQRGKSN-------SKGSDQ 489
                                |:.::..|..:|.:..|  .:...::..|:.:       ..|:..
  Rat   461 PAPEVEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRRDLLPTVRLVAGAAS 525

  Fly   490 SPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASSRGRDHHQQQHHQQQQQNHGSDHGASYRSDGK 554
            :.:.|..|..|.....|.   |.|.|...:.....|.......|..:::.....|.|....:|..
  Rat   526 AATSLFMVITGVVLCCWR---HGSLSKQKNLVRIPGSSEGSSAHGPEEETGSSEDRGPIVHTDHN 587

  Fly   555 SPHLTNHDAKSLTDDLDRMQDLKGWASRLSPISPILGLSMILGVGYLGPWP 605
            ...|..::|....|..:....::|       :|..|.|....|.|...|.|
  Rat   588 DLVLEENEALETKDPTNGYYKVRG-------VSVSLSLGEAPGGGLFLPPP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	24/110 (22%)
		IG_like	137..230	CDD:214653	24/110 (22%)
		IG_like	240..324	CDD:214653	26/92 (28%)
		IGc2	247..310	CDD:197706	20/71 (28%)
		Ig	327..419	CDD:299845	25/136 (18%)
		IG_like	343..420	CDD:214653	21/121 (17%)
Kirrel2	XP_038957463.1	IG_like	38..127	CDD:214653	23/109 (21%)
		Ig strand A'	40..44	CDD:409353	0/3 (0%)
		Ig strand B	48..57	CDD:409353	5/11 (45%)
		Ig strand C	62..66	CDD:409353	1/7 (14%)
		Ig strand D	75..85	CDD:409353	1/9 (11%)
		Ig strand E	88..100	CDD:409353	2/11 (18%)
		Ig strand F	107..115	CDD:409353	3/7 (43%)
		Ig strand G	117..127	CDD:409353	2/9 (22%)
		Ig	133..231	CDD:416386	28/101 (28%)
		Ig strand A	134..137	CDD:409353	0/2 (0%)
		Ig strand A'	140..144	CDD:409353	2/4 (50%)
		Ig strand B	151..158	CDD:409353	2/6 (33%)
		Ig strand C	164..169	CDD:409353	1/4 (25%)
		Ig strand C'	172..174	CDD:409353	1/1 (100%)
		Ig strand D	177..184	CDD:409353	0/6 (0%)
		Ig strand E	191..199	CDD:409353	1/7 (14%)
		Ig strand F	208..216	CDD:409353	4/7 (57%)
		Ig strand G	222..228	CDD:409353	0/5 (0%)
		Ig_3	234..303	CDD:404760	16/69 (23%)
		Ig strand B	252..256	CDD:409353	1/3 (33%)
		Ig strand C	266..270	CDD:409353	1/3 (33%)
		Ig strand E	283..286	CDD:409353	0/2 (0%)
		Ig strand F	292..301	CDD:409353	2/8 (25%)
		Ig strand G	309..312	CDD:409353	0/2 (0%)
		Ig	326..403	CDD:416386	9/76 (12%)
		Ig strand A'	327..332	CDD:409353	0/4 (0%)
		Ig strand B	335..344	CDD:409353	2/8 (25%)
		Ig strand C	350..354	CDD:409353	0/3 (0%)
		Ig strand C'	357..359	CDD:409353	1/1 (100%)
		Ig strand D	362..365	CDD:409353	0/2 (0%)
		Ig strand E	366..371	CDD:409353	0/4 (0%)
		Ig strand F	379..387	CDD:409353	0/7 (0%)
		Ig strand G	393..403	CDD:409353	0/9 (0%)
		Ig	405..509	CDD:416386	10/103 (10%)
		Ig strand A	406..410	CDD:409353	2/3 (67%)
		Ig strand A'	412..415	CDD:409353	0/2 (0%)
		Ig strand B	423..430	CDD:409353	0/6 (0%)
		Ig strand C	437..442	CDD:409353	1/4 (25%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	455..462	CDD:409353	0/6 (0%)
		Ig strand E	472..479	CDD:409353	0/6 (0%)
		Ig strand F	490..497	CDD:409353	1/6 (17%)
		Ig strand G	500..507	CDD:409353	0/6 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900