DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and Igsf9

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	361	Identity:	87/361 - (24%)
Similarity:	149/361 - (41%)	Gaps:	78/361 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVILLLILMSQQCYPQRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGP-------Y 72
            |.:.:|.:::||.             .|.:....:|::....|..|.|.|   ||.|       :
Mouse     5 LRLTVLSLIISQG-------------ADGRRKPEVVSVVGRAGESAVLGC---DLLPPAGHPPLH 53

  Fly    73 KVAWLRVDTQTILTIQNHVITKN------QRIGIANSEHKTWTMRIKDIKESDKGWYMCQI---- 127
            .:.|||......:.||..:.:..      .|:.:....    :::|:.::..|:|||.|::
Mouse    54 VIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQTGA----SLQIEGLRVEDQGWYECRVLFLD 114

  Fly   128 ----NTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPI 188
                ..|.......:|.|..||...:.|... :.|:|...|||:|.|.|||:|.:||:....
Mouse   115 QHSPEQDFANGSWVHLTVNSPPQFQETPPLV-LEVKELEAVTLRCVARGSPQPYVTWKFRGQ--- 175

  Fly   189 ELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITV--QNQLIG 251
            :|..|:..:.::...|.|..|.|...|.|.|.||:. ..|::....|:|..||:|.|  .|..:.
Mouse   176 DLGKGQGQVQVQNGTLWIRRVERGSAGDYTCQASSS-EGSITHATQLLVLGPPVIVVPPSNSTVN 239

  Fly   252 AVEGKGVTLDCESEAYPKSINY-WTRERGEIVPPGGKYSANVTEIGGYRNSMRLHIN-----PLT 310
            :  .:.|:|.|.:||||.::.| |.::           ..||..|...::.:|:.::     ..|
Mouse   240 S--SQDVSLACRAEAYPANLTYSWFQD-----------GVNVFHISRLQSRVRILVDGSLWLQAT 291

  Fly   311 QA-EFGSYRCVAKNSLGDTDGTIKLYRIPPNAVNYV 345
            |. :.|.|.||..|.          :..||:|..|:
Mouse   292 QPDDAGHYTCVPSNG----------FLHPPSASAYL 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/110 (19%)
		IG_like	51..137	CDD:214653	20/106 (19%)
		IG_like	153..237	CDD:214653	26/83 (31%)
		Ig	161..224	CDD:299845	22/62 (35%)
		IG_like	252..335	CDD:214653	20/89 (22%)
		Ig	258..333	CDD:143165	20/81 (25%)
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	19/88 (22%)
		Ig	136..223	CDD:386229	28/91 (31%)
		Ig_3	227..305	CDD:372822	23/90 (26%)
		Ig	341..404	CDD:386229
		Ig	436..500	CDD:319273
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900