DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and KIRREL2

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	398	Identity:	96/398 - (24%)
Similarity:	159/398 - (39%)	Gaps:	92/398 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RVEVPAEVIV----------DPKFSSPIVNMTAPVGRDAFLTCVVQDLGPY--KVAWLRVDTQTI 84
            |:.|||.:::          .|.|.....::...:|.:|.|.|.   ||.|  .|.|    |::.
Human     3 RMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCA---LGAYWGLVQW----TKSG 60

  Fly    85 LTI---------QNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLD 140
            |.:         ..:.|:.|    .||.:|   .:.|:.::..|:..|.||.....::|:...|.
Human    61 LALGGQRDLPGWSRYWISGN----AANGQH---DLHIRPVELEDEASYECQATQAGLRSRPAQLH 118

  Fly   141 VVVPPD---ILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGT 202
            |:|||:   :|..| |..:|....:|:|.:......|.|.:.|.|: ||.::.||..:.:..|||
Human   119 VLVPPEAPQVLGGP-SVSLVAGVPANLTCRSRGDARPTPELLWFRD-GVLLDGATFHQTLLKEGT 181

  Fly   203 DLVIPNVR-----RHHMGA-YLCIA-SNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTL 260
            ...:.:..     .|..|| ::|.| |..:|......|||.:.:||.:|:........||:.|..
Human   182 PGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 246

  Fly   261 DCESEAYPKSINY-WTR-------ERG---EIVPPGGKYSANVT-----EIGGYRNSMRLHI--N 307
            .|::.|.|....| |.:       .||   |:|......:..|:     .:|....|..|.:  .
Human   247 LCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFG 311

  Fly   308 PLTQA----------EFGSYRCVAKNS---------------LGDTDGTIKLYRI-PPNAVNYVE 346
            |:.||          |..|:.|..:.:               || :..|::|..: |.:|.:||.
Human   312 PILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLG-SGATLRLPSVGPEDAGDYVC 375

  Fly   347 NFEARHKG 354
            ..||...|
Human   376 RAEAGLSG 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	23/100 (23%)
		IG_like	51..137	CDD:214653	22/96 (23%)
		IG_like	153..237	CDD:214653	25/90 (28%)
		Ig	161..224	CDD:299845	19/69 (28%)
		IG_like	252..335	CDD:214653	25/125 (20%)
		Ig	258..333	CDD:143165	23/117 (20%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	23/102 (23%)
		IGc2	38..106	CDD:197706	21/81 (26%)
		I-set	126..224	CDD:254352	27/99 (27%)
		Ig2_KIRREL3-like	141..223	CDD:143236	23/82 (28%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	15/74 (20%)
		IG_like	234..308	CDD:214653	16/73 (22%)
		Ig	312..395	CDD:299845	17/73 (23%)
		I-set	317..395	CDD:254352	14/68 (21%)
		Ig	397..501	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810