DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and zgc:152904

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001070212.1	Gene:	zgc:152904 / 767777	ZFINID:	ZDB-GENE-060929-856	Length:	809	Species:	Danio rerio

Alignment Length:	451	Identity:	101/451 - (22%)
Similarity:	163/451 - (36%)	Gaps:	95/451 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EVPAEVIVDPKFSSP--IVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQ 96
            ::..:|.|.|..|.|  ..|.||........|||.......:|.|.         .:.|.|..::
Zfish   169 DIVVQVNVPPVLSVPQQSFNATADYQESVTFTCVTSGSPDPQVTWY---------WKGHAIEHSE 224

  Fly    97 RIGIANSEHKTWTMRIKDIKESDKGWYMCQIN--TDPMKSQMGYLDVVVPPDILDYPTSTDMVVR 159
            :..:........|:.:|:||::|.|.|||:.:  ....:||: :|.|.|.|.|......|.:
Zfish   225 QYVLNTMNGGKSTLTVKNIKQTDGGPYMCRASNKAGSSESQL-FLKVFVQPHITQLRNVTAV--- 285

  Fly   160 EGSNVTLKCAATGSPEPTITWRRESG--------------VPIELATGEEVMSIEGTDLVIPNVR 210
            |||...:.|.|.|.|.|.|:|||.|.              |.:....|:.:::|.|..|
Zfish   286 EGSAAMISCTAEGEPLPEISWRRASDGHSFTDGEKSKDGRVEVRGRHGKSMLTISGVQL------ 344

  Fly   211 RHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWT 275
             ...|.:.|.|.:.: ....|.:.|.:.:.|.......:..:.||..|.:.||.::.|.:...|.
Zfish   345 -SDWGRFDCEALSRI-GGHQKSMFLDIEYAPKFQTNQSIFYSWEGNPVNISCEVKSNPAATMLWR 407

  Fly   276 RERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLG---------DTDGT 331
            |||..|...|   ::|: .|........|.:.|::..:||.|.|.|:|::|         ..|..
Zfish   408 RERFTISSQG---TSNI-RIHSTDGRSLLEVTPVSDRDFGRYNCTARNNIGARYQEFILAQADVP 468

  Fly   332 IKLYRIPPNAVN---------------------YVENF----------EARHKGKKRTKSSESHH 365
            ...|.:...||:                     |:.|:          .||..|.:......|..
Zfish   469 SSPYSVRMTAVSQRMATVSFMKPDSHGGVPISFYIINYRDTSSAQEWRSARTHGVQTAVVLTSLE 533

  Fly   366 PARAQEHSGEDMENPGKRK-------ADLSLGAESIDSIYGNSAAGSRRR-----QDLGGV 414
            |....|.....:...|:.:       ..|.:...|..:::|....|...|     ||.||:
Zfish   534 PNTTYEVRVSAVNGKGQGEFSHTESFQTLPIREPSPPTVHGQRGVGKAYRLGLVKQDDGGM 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	22/91 (24%)
		IG_like	51..137	CDD:214653	21/87 (24%)
		IG_like	153..237	CDD:214653	24/97 (25%)
		Ig	161..224	CDD:299845	20/76 (26%)
		IG_like	252..335	CDD:214653	24/91 (26%)
		Ig	258..333	CDD:143165	22/83 (27%)
zgc:152904	NP_001070212.1	Ig	1..81	CDD:299845
		IG_like	2..80	CDD:214653
		IGc2	97..158	CDD:197706
		Ig	177..273	CDD:299845	26/105 (25%)
		I-set	184..270	CDD:254352	22/95 (23%)
		Ig	272..369	CDD:299845	27/107 (25%)
		I-set	274..367	CDD:254352	25/103 (24%)
		IG_like	385..462	CDD:214653	23/80 (29%)
		IGc2	386..454	CDD:197706	22/71 (31%)
		FN3	468..561	CDD:238020	12/92 (13%)
		fn3	<591..650	CDD:278470	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010