DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and BSG

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001719.2	Gene:	BSG / 682	HGNCID:	1116	Length:	385	Species:	Homo sapiens

Alignment Length:	319	Identity:	69/319 - (21%)
Similarity:	118/319 - (36%)	Gaps:	71/319 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 EHKTWTMRIKDIKESDKGWYMCQINTDPMKSQM-----------GYLDVVVPPDILDYPTSTDMV 157
            :|...|:.|..:.|.|.|.|.|:.:.||.::.:           ..:.:|:.|..: :.|..|:
Human    87 QHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTV-FTTVEDL- 149

  Fly   158 VREGSNVTLKCAATGSPEPTITWRR--ESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCI 220
               ||.:.|.|:...| ...:|..|  :.||.::    |:.:..:.|:..:.:  ....|.|.|:
Human   150 ---GSKILLTCSLNDS-ATEVTGHRWLKGGVVLK----EDALPGQKTEFKVDS--DDQWGEYSCV 204

  Fly   221 ASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINY-WTRERGEIVPP 284
                ..|.......:.:|.||.:..........||:...|.|:||:.|...:: |.:    |...
Human   205 ----FLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYK----ITDS 261

  Fly   285 GGKYSANVTE----IGGYRNSMRLHINPLT-QAEFGSYRCVAKNSLGDTDGTIKLYRIPPN---- 340
            ..|...|.:|    :...:....|||..|. :|:.|.|||...:|.|.....|.| |:..:
Human   262 EDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITL-RVRSHLAAL 325

  Fly   341 ------------AVNYVENFEARHK----------GKKRTKSSESHHPARAQEHSGEDM 377
                        .|..:..:|.|.|          |....|||..|     |...|:::
Human   326 WPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQH-----QNDKGKNV 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	10/47 (21%)
		IG_like	51..137	CDD:214653	10/43 (23%)
		IG_like	153..237	CDD:214653	16/85 (19%)
		Ig	161..224	CDD:299845	14/64 (22%)
		IG_like	252..335	CDD:214653	24/88 (27%)
		Ig	258..333	CDD:143165	21/80 (26%)
BSG	NP_001719.2	IG_like	29..113	CDD:214653	8/25 (32%)
		Ig	40..114	CDD:143165	8/26 (31%)
		Essential for interaction with KDR/VEGFR2. /evidence=ECO:0000269\|PubMed:25825981	195..199		0/3 (0%)
		Ig	219..317	CDD:299845	27/102 (26%)
		IG_like	228..318	CDD:214653	25/94 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..385		7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910