DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	459	Identity:	110/459 - (23%)
Similarity:	181/459 - (39%)	Gaps:	130/459 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EVIVDPKFSSP------------IVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNH 90
            |.||...|.||            ..|...|.|::   |.|..|:....:..|.|:.|.:|  :::
Mouse   206 ESIVSTLFISPGDVENGQSIVCRATNKAIPGGKE---TSVTIDIQHPPLVNLSVEPQPVL--EDN 265

  Fly    91 VIT--KNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQIN----TDPMKSQM----------GYL 139
            ::|  .:.:...|.:::: |..|...|||:....|...::    ::|:..::          ..:
Mouse   266 IVTFHCSAKANPAVTQYR-WAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329

  Fly   140 DVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITW-RRESGVPIELATGEEVMSIEGTD 203
            ||...|.:...|.|  ::|..||:....||..|:|..||.| :|.|||         |:|.|.|
Mouse   330 DVYFGPRMTSEPQS--LLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGV---------VLSNEKT- 382

  Fly   204 LVIPNVRRHHMGAYLCIASNGVPPSV---SKRITLVVHFPPMITVQNQLIGAVEGKGVTLDC--E 263
            |.:.:||:...|.|:|.|   |.|.|   .:.:||.|:.||:|: ..|...|:.|:...:.|  .
Mouse   383 LTLKSVRQEDAGKYVCRA---VVPRVGAGEREVTLTVNGPPIIS-STQTQHALHGEKGQIKCFIR 443

  Fly   264 SEAYPKSINYWTRERGEIVPPG--GKYSANV--TEIGGYRNSMRLHINPLTQAEFGS-YRCVAKN 323
            |...|..|.:..:|  .::..|  |:|:...  ||.|....   |.|:.:.:|:|.: |.|.|.|
Mouse   444 STPPPDRIAWSWKE--NVLESGTSGRYTVETVNTEEGVIST---LTISNIVRADFQTIYNCTAWN 503

  Fly   324 SLGDTDGTIKLYRIPPNAVNYVENFEARHKGKKRTKSSESHHPARAQEHSGEDMENPGKRKADLS 388
            |.|.....|:|                                    :..|.:|      |:...
Mouse   504 SFGSDTEIIRL------------------------------------KEQGSEM------KSGAG 526

  Fly   389 LGAESID-SIYGNSAAGSRRRQDLGGVLLLLLPVAVAVAMSLATA-------------GVMRETQ 439
            |.|||:. ::....|.|:       ||..|:| :|..||...|.:             |..::.:
Mouse   527 LEAESVPMAVIIGVAVGA-------GVAFLVL-MATIVAFCCARSQRSTGGRPGISGRGTEKKAR 583

  Fly   440 MTLP 443
            :.||
Mouse   584 LRLP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	19/105 (18%)
		IG_like	51..137	CDD:214653	19/101 (19%)
		IG_like	153..237	CDD:214653	31/87 (36%)
		Ig	161..224	CDD:299845	24/63 (38%)
		IG_like	252..335	CDD:214653	24/89 (27%)
		Ig	258..333	CDD:143165	21/81 (26%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353
		Ig strand C	78..82	CDD:409353
		Ig strand C'	84..87	CDD:409353
		Ig strand D	97..101	CDD:409353
		Ig strand E	104..116	CDD:409353
		Ig strand G	132..143	CDD:409353
		IgI_2_KIRREL3-like	149..246	CDD:409416	11/42 (26%)
		Ig strand B	166..170	CDD:409416
		Ig strand C	180..184	CDD:409416
		Ig strand E	210..214	CDD:409416	0/3 (0%)
		Ig strand F	224..229	CDD:409416	0/4 (0%)
		Ig strand G	239..242	CDD:409416	1/5 (20%)
		Ig	<267..334	CDD:416386	11/67 (16%)
		Ig strand B	267..274	CDD:409353	1/6 (17%)
		Ig strand C	279..286	CDD:409353	1/7 (14%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	1/3 (33%)
		Ig strand E	304..310	CDD:409353	0/5 (0%)
		Ig strand G	321..334	CDD:409353	2/12 (17%)
		Ig	335..416	CDD:416386	33/95 (35%)
		Ig strand A'	343..347	CDD:409353	1/5 (20%)
		Ig strand B	350..360	CDD:409353	3/9 (33%)
		Ig strand C	365..371	CDD:409353	3/5 (60%)
		Ig strand E	381..387	CDD:409353	2/6 (33%)
		IgI_5_KIRREL3	418..515	CDD:409479	29/138 (21%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	1/6 (17%)
		Ig strand F	496..501	CDD:409479	2/4 (50%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810