DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and IGSF9

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	358	Identity:	90/358 - (25%)
Similarity:	151/358 - (42%)	Gaps:	72/358 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVILLLILMSQQCYPQRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGP-------Y 72
            |.:.:|.:::||.             .|.:....:|::....|....|.|   ||.|       :
Human     5 LGLAVLSLVISQG-------------ADGRGKPEVVSVVGRAGESVVLGC---DLLPPAGRPPLH 53

  Fly    73 KVAWLRVDTQTILTIQNHVITKN---QRIGIANSEHKTWTMRIKDIKESDKGWYMCQI------- 127
            .:.|||......:.||..:.:..   ..:|....: |..:::|:.::..|:|||.|::
Human    54 VIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ-KGASLQIEGLRVEDQGWYECRVFFLDQHI 117

  Fly   128 -NTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELA 191
             ..|.......:|.|..||...:.|.:. :.|:|...|||:|.|.|||.|.:||:....   :|.
Human   118 PEDDFANGSWVHLTVNSPPQFQETPPAV-LEVQELEPVTLRCVARGSPLPHVTWKLRGK---DLG 178

  Fly   192 TGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITV--QNQLIGAVE 254
            .|:..:.::...|.|..|.|...|.|.|.||: ...|.:....|:|..||:|.|  :|..:.|
Human   179 QGQGQVQVQNGTLRIRRVERGSSGVYTCQASS-TEGSATHATQLLVLGPPVIVVPPKNSTVNA-- 240

  Fly   255 GKGVTLDCESEAYPKSINY-WTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINP-----LTQA- 312
            .:.|:|.|.:||||.::.| |.::           :.||..|...:..:|:.::.     .||.
Human   241 SQDVSLACHAEAYPANLTYSWFQD-----------NINVFHISRLQPRVRILVDGSLRLLATQPD 294

  Fly   313 EFGSYRCVAKNSLGDTDGTIKLYRIPPNAVNYV 345
            :.|.|.||..|.|        |:  ||:|..|:
Human   295 DAGCYTCVPSNGL--------LH--PPSASAYL 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/107 (20%)
		IG_like	51..137	CDD:214653	20/103 (19%)
		IG_like	153..237	CDD:214653	26/83 (31%)
		Ig	161..224	CDD:299845	22/62 (35%)
		IG_like	252..335	CDD:214653	22/89 (25%)
		Ig	258..333	CDD:143165	21/81 (26%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	22/111 (20%)
		IG_like	28..110	CDD:214653	19/85 (22%)
		I-set	136..223	CDD:254352	28/91 (31%)
		Ig	154..220	CDD:143165	23/69 (33%)
		Ig_3	226..305	CDD:290638	25/91 (27%)
		IG_like	233..319	CDD:214653	28/108 (26%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810