DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and ush2a

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	412	Identity:	77/412 - (18%)
Similarity:	134/412 - (32%)	Gaps:	124/412 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHK 106
            ||:...|      |:||....|.:       :::|...|:.....:...::...|.|.:::|:|.
Zfish  1067 DPQQQPP------PLGRVLNSTTI-------ELSWRTPDSPNSNALMYTLLRDTQIIHVSHSQHP 1118

  Fly   107 TWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVVVPPDILDYPTSTDMV-------VREGSNV 164
            ..||...|...|....|..|:.|..::|.                ||:.:|       |.|...:
Zfish  1119 FGTMHFIDTALSPYTLYSYQLITSNIRSN----------------TSSSVVTLRTLSAVPEQEEL 1167

  Fly   165 TLKCAATGSP-EPTITWRRESGV--PIELATGEEVMSIEG----------TDLVIPNVR---RHH 213
            .|.......| ..:..|......  ||:..|...:..:.|          |:.....::   |::
Zfish  1168 QLTLVGRAKPNSASFNWTEPLNTTGPIDNYTLSSIQDLSGEKRIYYTGLQTEATAEELQPFTRYN 1232

  Fly   214 MGAYLC------------IASNGVPP--SVSKRIT------LVVHFPPMITVQNQLIGAVEGKGV 258
            .....|            :.:..:||  ..:.:||      |.|.:.|.: :.|.:|...|   :
Zfish  1233 FSLKACTDGGCARSESLVVQTAQIPPEQQPAPKITTLGSSQLKVDWEPPV-LPNGIIIRYE---L 1293

  Fly   259 TLDCESEAYPKSINYWTRER-----GEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAE----- 313
            .:...:|....:.:|.|.:|     |.:.|.....|||.              |.||..|
Zfish  1294 FMQLLNELQRNASSYGTEQRVFLSSGWLNPRPSLSSANE--------------NALTPPESTVVV 1344

  Fly   314 -----FGSYR-----------CVAKNSLGDTDGTIKLYRIPPNAVNYVENFEARHKGK----KRT 358
                 |.:||           .::..::|.|...:..|..||. |:.|.:...|...:    |..
Zfish  1345 SNLQPFSTYRFRVLTVNMAGSVLSDWAVGRTAEGVPEYMAPPQ-VSAVSSSSLRVSWETPRDKDV 1408

  Fly   359 KSSESHHPARAQEHSGEDMENP 380
            :...:.:  |...|. |.|.||
Zfish  1409 RGEVTEY--RVNLHQ-EQMSNP 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	18/89 (20%)
		IG_like	51..137	CDD:214653	18/85 (21%)
		IG_like	153..237	CDD:214653	19/126 (15%)
		Ig	161..224	CDD:299845	10/90 (11%)
		IG_like	252..335	CDD:214653	19/108 (18%)
		Ig	258..333	CDD:143165	18/100 (18%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020	9/75 (12%)
		FN3	1264..1375	CDD:238020	25/128 (20%)
		FN3	1386..1469	CDD:214495	11/46 (24%)
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900