DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and cadm1b

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001107024.1	Gene:	cadm1b / 562183	ZFINID:	ZDB-GENE-080327-34	Length:	411	Species:	Danio rerio

Alignment Length:	373	Identity:	91/373 - (24%)
Similarity:	151/373 - (40%)	Gaps:	83/373 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHKTWTMRIKDI 115
            |::...|..|.::|.|::.....:..|..:.|||. .::....|:.|..:.|.......:.:.::
Zfish    51 NVSVVEGETAIISCRVKNNDDSVIQLLNPNRQTIY-FRDVRPLKDSRFQLVNFSDNELLVSLSNV 114

  Fly   116 KESDKGWYMCQINTDPMKSQMGYLDVVVPP--DILDYPTSTDMVVREGSNVTLKCAATGS-PEPT 177
            ..||:|.|:||:.|||.:.....:.|:|||  .||:   |.:.:|.||:...:.|.|.|| |..|
Zfish   115 SLSDEGRYVCQLYTDPPQEAYADITVLVPPGNPILE---SREEIVSEGNETEITCTAMGSKPAST 176

  Fly   178 ITWRRESGVPIE-LATGEEVMS--IEGTDLVIPNVRRHHMG-AYLCIASNGVPPSV--------- 229
            |.|.: ...|:: .||.||:..  ...|..:...|.:...| |.:||..:   |:|
Zfish   177 IKWMK-GDQPLQGEATVEELYDRMFTVTSRLRLTVSKEDDGVAVICIIDH---PAVKDFQAQKYL 237

  Fly   230 ----SKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPK--SINYWTRERGEIVPPGGKY 288
                ...:.:||.||..:|        .||:.:.|.|:::..|:  .|| |.:     |......
Zfish   238 EVQYKPEVKIVVGFPEGLT--------REGENLELTCKAKGKPQPHQIN-WLK-----VDDDFPS 288

  Fly   289 SANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRI------PPNAVNY--- 344
            .|.||       ...|.|..|.::..|:|||||.|.:|:......||..      .|..:::
Zfish   289 HALVT-------GSDLFIENLNKSYNGTYRCVASNLVGEAYDDYILYVYDSRADGAPQKIDHAVI 346

  Fly   345 -----------------VENFEARHKGKKRTKSSESHHPARAQEHSGE 375
                             :..:.|||||...|      |.|:..:.:.:
Zfish   347 GGVVAVVVFAMLCLLIVLGRYFARHKGTYFT------HEAKGADDAAD 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/89 (24%)
		IG_like	51..137	CDD:214653	21/85 (25%)
		IG_like	153..237	CDD:214653	25/101 (25%)
		Ig	161..224	CDD:299845	20/67 (30%)
		IG_like	252..335	CDD:214653	23/84 (27%)
		Ig	258..333	CDD:143165	21/76 (28%)
cadm1b	NP_001107024.1	Ig1_Necl-2	46..140	CDD:143289	21/89 (24%)
		IG_like	51..140	CDD:214653	21/89 (24%)
		Ig	161..242	CDD:299845	21/84 (25%)
		Ig_3	242..316	CDD:290638	26/94 (28%)
		IG_like	252..329	CDD:214653	26/97 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910