DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and hmcn1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_005160777.1	Gene:	hmcn1 / 559150	ZFINID:	ZDB-GENE-041014-322	Length:	5623	Species:	Danio rerio

Alignment Length:	450	Identity:	112/450 - (24%)
Similarity:	175/450 - (38%)	Gaps:	52/450 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LILMSQQCYPQRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTIL 85
            |.:.:.|...:|..|..:|.|.|..:....|:|..|.....|:|....:....|:|.: :||.:.
Zfish  3767 LCMATNQAGTERKRVDLQVYVPPSIAEGPTNITVTVNVQTTLSCEATGIPKPSVSWTK-NTQALN 3830

  Fly    86 TIQN----HVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDP-MKSQMGYLDVVVPP 145
            |.||    .:::....:.||.|             ..|...|.|.::.:. .:|:...|.|.|||
Zfish  3831 TDQNQNMYRLLSSGSLVVIAPS-------------VEDTALYECVVSNEAGQESRAIQLTVHVPP 3882

  Fly   146 DILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELA-TGEEVMSIEGTDLVIPNV 209
            .|.|  .:|::||...|.|.:.|.|:|.|.|.:.|.::.   :.|| .||....:....|.|...
Zfish  3883 SIAD--EATELVVSRLSPVVIGCTASGVPHPVLYWSKDG---LRLAKDGEGFTILPSGPLEITAA 3942

  Fly   210 RRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYW 274
            ...|.|.|.|:|.|.. .:..:.:.|.||..|:|......:..:....|||.|.:...|:....|
Zfish  3943 DLSHSGRYSCVAKNAA-GTAHRHVQLTVHESPVIQSHPSTLDVILNNHVTLPCRATGSPRPTITW 4006

  Fly   275 TRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKL-YRIP 338
            .:|...|...||.::  |...||      |.|:.....:.|:|.|||:|..|...|..|| .::|
Zfish  4007 QKEGINIFTTGGGFT--VLPNGG------LQISKAKVEDSGTYMCVAQNPAGTALGKTKLRVQVP 4063

  Fly   339 PNAVNYVENFE-ARHKGKKRTKSSESHHPARAQEHSGEDMENPGKRKADLSLGAESI-------D 395
            |...:.:..:. |.........:||.........|....:.:...|:..||.||..|       .
Zfish  4064 PVITSDIRAYTVALDVSVTLQCNSEGFPTPSVSWHKDGQLLSESVRQRVLSTGALQIAFAQPGDT 4128

  Fly   396 SIYGNSAAGSRRRQDLGGVLLLLLPVAVAVAMSLATAGVMRETQMTL-------PPQTLT 448
            ..|..:.|.......|...|.:.:|.::.|..|  ...|:..||..|       |..|:|
Zfish  4129 GRYTCTVANVAGSSSLDISLTVQIPPSIRVGES--EVSVVENTQALLTCVADGVPQPTIT 4186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	20/94 (21%)
		IG_like	51..137	CDD:214653	19/90 (21%)
		IG_like	153..237	CDD:214653	24/84 (29%)
		Ig	161..224	CDD:299845	19/63 (30%)
		IG_like	252..335	CDD:214653	25/83 (30%)
		Ig	258..333	CDD:143165	23/74 (31%)
hmcn1	XP_005160777.1	VWA_2	36..206	CDD:290253
		IG_like	443..510	CDD:214653
		I-set	514..600	CDD:254352
		ig	522..596	CDD:278476
		I-set	604..688	CDD:254352
		Ig	618..689	CDD:299845
		I-set	694..781	CDD:254352
		IGc2	708..771	CDD:197706
		I-set	785..876	CDD:254352
		Ig	789..876	CDD:299845
		IG	888..969	CDD:214652
		IGc2	895..959	CDD:197706
		I-set	973..1060	CDD:254352
		Ig	990..1059	CDD:299845
		IG	1084..1162	CDD:214652
		Ig	1092..1159	CDD:143165
		I-set	1166..1251	CDD:254352
		IGc2	1179..1241	CDD:197706
		I-set	1251..1348	CDD:254352
		Ig	1254..1348	CDD:299845
		I-set	1360..1441	CDD:254352
		IGc2	1367..1431	CDD:197706
		I-set	1450..1535	CDD:254352
		IGc2	1461..1525	CDD:197706
		IG_like	1547..1628	CDD:214653
		Ig	1558..1625	CDD:143165
		I-set	1641..1722	CDD:254352
		Ig	1641..1718	CDD:299845
		Ig	1725..1817	CDD:299845
		IG	1738..1815	CDD:214652
		Ig	1818..1908	CDD:299845
		IG	1826..1908	CDD:214652
		IG	1922..2001	CDD:214652
		Ig	1927..2001	CDD:299845
		IG	2014..2093	CDD:214652
		IGc2	2019..2083	CDD:197706
		Ig	2096..2186	CDD:299845
		IG_like	2107..2184	CDD:214653
		Ig	2187..2280	CDD:299845
		I-set	2197..2277	CDD:254352
		Ig	2292..2371	CDD:299845
		IG	2292..2369	CDD:214652
		I-set	2373..2463	CDD:254352
		IGc2	2391..2453	CDD:197706
		IG	2476..2556	CDD:214652
		IGc2	2484..2546	CDD:197706
		IG	2572..2652	CDD:214652
		IGc2	2583..2642	CDD:197706
		I-set	2670..2751	CDD:254352
		IGc2	2678..2741	CDD:197706
		IG	2774..2850	CDD:214652
		IGc2	2777..2840	CDD:197706
		I-set	2864..2945	CDD:254352
		Ig	2864..2938	CDD:299845
		Ig	2949..3039	CDD:299845
		IG_like	2957..3037	CDD:214653
		I-set	3051..3132	CDD:254352
		IGc2	3059..3122	CDD:197706
		I-set	3154..3226	CDD:254352
		Ig	3154..3223	CDD:143165
		Ig	3229..3323	CDD:299845
		I-set	3238..3321	CDD:254352
		IG	3335..3415	CDD:214652
		Ig	3343..3415	CDD:299845
Ig	3418..3508	CDD:299845
IG	3428..3508	CDD:214652
IG	3520..3601	CDD:214652
Ig	<3533..3603	CDD:299845
I-set	3614..3694	CDD:254352
IGc2	3620..3684	CDD:197706
Ig	3697..3787	CDD:299845	5/19 (26%)
IG_like	3704..3785	CDD:214653	4/17 (24%)
Ig	3788..3878	CDD:299845	21/103 (20%)
I-set	3789..3878	CDD:254352	21/102 (21%)
IG_like	3891..3969	CDD:214653	23/81 (28%)
Ig	3899..3968	CDD:299845	19/72 (26%)
IG_like	3979..4060	CDD:214653	25/88 (28%)
Ig	3990..4052	CDD:299845	22/69 (32%)
I-set	4064..4150	CDD:254352	15/85 (18%)
IGc2	4080..4140	CDD:197706	11/59 (19%)
Ig	4161..4241	CDD:299845	7/27 (26%)
IG_like	4161..4241	CDD:214653	7/27 (26%)
I-set	4245..4324	CDD:254352
IGc2	4260..4320	CDD:197706
Ig	4352..4420	CDD:299845
I-set	4425..4511	CDD:254352
Ig	4439..4512	CDD:299845
TSP1	4518..4569	CDD:214559
TSP1	4583..4626	CDD:214559
TSP1	4631..4683	CDD:214559
TSP1	4688..4740	CDD:214559
TSP1	4745..4797	CDD:214559
TSP1	4802..4854	CDD:214559
nidG2	4855..5070	CDD:238158
EGF_CA	5091..5130	CDD:214542
EGF_CA	5131..5174	CDD:284955
EGF_CA	5176..5213	CDD:214542
EGF_CA	5214..5251	CDD:214542
EGF_CA	5256..5297	CDD:284955
EGF_CA	5299..5338	CDD:214542
EGF_CA	5420..5459	CDD:214542
EGF_CA	5460..5496	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910