DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and sdk1a

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	347	Identity:	72/347 - (20%)
Similarity:	135/347 - (38%)	Gaps:	50/347 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILMSQQCYPQRVEVPAEVIVDPKFSS-PIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTIL 85
            :|:.....|........:...|.|:: |...|...|.:...:.|..:.:...|:.|.: |...:.
Zfish   395 LLLDSSVKPAEARAFLSITEAPYFTAEPRRKMMGEVEKSVDIQCQARGVPMPKLEWYK-DAVPLS 458

  Fly    86 TIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQM-GYLDV-------V 142
            .:      .|.|..|.:|    ..::::.::.||.|.:.|.......::|: .||||       .
Zfish   459 KL------NNPRYKIISS----MGLQVRKLQPSDAGIFQCFARNSAGEAQVHTYLDVTSMAPAFT 513

  Fly   143 VPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGE----EVMSIEGTD 203
            .||        .|:.|.:|:.....|..:|:|:|.|.|||::.:   ||:|.    ....:|...
Zfish   514 APP--------LDITVTDGAVAAFTCRVSGAPKPAIVWRRDTQI---LASGSVQIPRFTLLESGG 567

  Fly   204 LVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYP 268
            |.|..|.....|.|.|.|:|. ..:::...:|.|.....|:........::|....|:|.:...|
Zfish   568 LQIQPVVLQDTGNYTCYAANS-EGAINASASLTVWSRTSISSPPTDRRVIKGTTAILECGATHDP 631

  Fly   269 K-SINYWTRERGEIV--PPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGD--T 328
            : .:.|..::..|:|  ..||:.|.         ....|||:.....:.|:|.|...:..|:  .
Zfish   632 RVGVRYVWKKDEELVSHSRGGRISL---------QEGSLHISQTWSGDIGNYTCDVISEAGNESK 687

  Fly   329 DGTIKLYRIPPNAVNYVENFEA 350
            :..:::..:|.:..|...:..|
Zfish   688 EARLEVIELPHSPRNLQASLNA 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	17/90 (19%)
		IG_like	51..137	CDD:214653	15/86 (17%)
		IG_like	153..237	CDD:214653	24/87 (28%)
		Ig	161..224	CDD:299845	20/66 (30%)
		IG_like	252..335	CDD:214653	17/87 (20%)
		Ig	258..333	CDD:143165	16/79 (20%)
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352
		Ig	125..204	CDD:299845
		IG_like	222..302	CDD:214653
		Ig	236..287	CDD:299845
		Ig_3	322..394	CDD:290638
		I-set	323..412	CDD:254352	2/16 (13%)
		I-set	416..505	CDD:254352	20/99 (20%)
		Ig	436..500	CDD:299845	13/74 (18%)
		I-set	510..600	CDD:254352	26/101 (26%)
		Ig	527..600	CDD:299845	21/76 (28%)
		I-set	605..693	CDD:254352	18/96 (19%)
		Ig	610..693	CDD:299845	17/91 (19%)
		FN3	697..788	CDD:238020	3/13 (23%)
		fn3	800..886	CDD:278470
		FN3	901..997	CDD:238020
		FN3	1002..1090	CDD:238020
		FN3	1100..1196	CDD:238020
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810