DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	339	Identity:	89/339 - (26%)
Similarity:	142/339 - (41%)	Gaps:	64/339 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGI 100
            |.::.:...|:...:|...|.|::   |.:..|:.......|.::.||:...:..|.|..   ..
Human   189 PTDLDIGRVFTCRSMNEAIPSGKE---TSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQ---AT 247

  Fly   101 ANSE--HKTWT---MRIKDIKES------DKGWY----MCQINTDPMKSQMGYL-------DVVV 143
            ||.|  ...|.   ..|:|..||      |..::    .|:::.....:.:..|       .:||
Human   248 ANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVV 312

  Fly   144 PPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWR--------RESGVPIELATGEEVMSIE 200
            .|.    ||:||:    ||:|||.|...|:|..|:||.        |..|.|.|.|...:|:| .
Human   313 DPK----PTTTDI----GSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLS-N 368

  Fly   201 GTDLVIPNVRRHHMGAYLCIASNGVPPSV---SKRITLVVHFPPMIT---VQNQLIGAVEGKGVT 259
            ...|::.:|.:...|.|.|.|   :.|.:   .:.:.|.|:.||:|:   ||.    ||.|.|..
Human   369 SNQLLLKSVTQADAGTYTCRA---IVPRIGVAEREVPLYVNGPPIISSEAVQY----AVRGDGGK 426

  Fly   260 LDC--ESEAYPKSINYWTRERGEIVPPGGKYSANVTEIG-GYRNSMRLHINPLTQAEFGS-YRCV 320
            ::|  .|...|..|.:..:|....|....:|:...|..| |..::  |.||.:.:|:|.: |.|.
Human   427 VECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLST--LTINNVMEADFQTHYNCT 489

  Fly   321 AKNSLGDTDGTIKL 334
            |.||.|.....|:|
Human   490 AWNSFGPGTAIIQL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/111 (19%)
		IG_like	51..137	CDD:214653	20/100 (20%)
		IG_like	153..237	CDD:214653	28/94 (30%)
		Ig	161..224	CDD:299845	24/70 (34%)
		IG_like	252..335	CDD:214653	27/87 (31%)
		Ig	258..333	CDD:143165	21/78 (27%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352
		Ig	25..116	CDD:299845
		Ig2_KIRREL3-like	138..219	CDD:143236	6/32 (19%)
		I-set	223..304	CDD:254352	16/83 (19%)
		Ig_2	227..305	CDD:290606	16/80 (20%)
		Ig_2	311..405	CDD:290606	33/105 (31%)
		IG_like	314..405	CDD:214653	31/102 (30%)
		Ig5_KIRREL3	407..504	CDD:143306	32/103 (31%)
		IG_like	416..504	CDD:214653	29/94 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810