Protein Alignment DIP-eta and NTM

DIOPT Version :10

• Sequence 1: NP_608946.3
• Gene: DIP-eta / 33793
• FlyBaseID: FBgn0031725
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001338930.1
• Gene: NTM / 50863
• HGNCID: 17941
• Length: 367
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 100/340 - (29%)
• Similarity: 164/340 - (48%)
• Gaps: 50/340 - (14%)

  Fly    42 DPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHK 106
            |..|...:.|:|...|..|.|.|.: |....:||||  :..|||...|.....:.|:.:.::...
Human    35 DATFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWL--NRSTILYAGNDKWCLDPRVVLLSNTQT 96

  Fly   107 TWTMRIKDIKESDKGWYMCQINTD--PMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCA 169
            .:::.|:::...|:|.|.|.:.||  |..|:: :|.|.|.|.|::  .|:|:.:.||:|::|.|.
Human    97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRV-HLIVQVSPKIVE--ISSDISINEGNNISLTCI 158

  Fly   170 ATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRIT 234
            |||.||||:|||..|...:...:.:|.:.|:|       :.|...|.|.|.|||.|...|.:|:.
Human   159 ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPVVRRVK 216

  Fly   235 LVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYR 299
            :.|::||.|: :.:..|...|:..||.||:.|.|.:...|.::...::.  ||....|      .
Human   217 VTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE--GKKGVKV------E 272

  Fly   300 N----SMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRI---------------------PP 339
            |    |..:..| :::.::|:|.|||.|.||.|:.:|.|:.:                     .|
Human   273 NRPFLSKLIFFN-VSEHDYGNYTCVASNKLGHTNASIMLFELNEPTSSTLLQEVKTTALTPWKGP 336

  Fly   340 NAVNYVENFEARHKG 354
            .||:.|.|..:|..|
Human   337 GAVSEVSNGTSRRAG 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_608946.3	IG_like	51..137	CDD:214653	25/87 (29%)
		Ig strand B	60..64	CDD:409353	2/3 (67%)
		Ig strand C	73..77	CDD:409353	2/3 (67%)
		Ig strand E	108..112	CDD:409353	0/3 (0%)
		Ig strand F	122..127	CDD:409353	2/4 (50%)
		Ig strand G	134..137	CDD:409353	1/2 (50%)
		IgI_1_MuSK	145..237	CDD:409562	33/91 (36%)
		Ig strand A	145..148	CDD:409562	1/2 (50%)
		Ig strand A'	153..158	CDD:409562	2/4 (50%)
		Ig strand B	164..171	CDD:409562	2/6 (33%)
		Ig strand C	177..182	CDD:409562	3/4 (75%)
		Ig strand C'	184..186	CDD:409562	1/1 (100%)
		Ig strand D	194..197	CDD:409562	1/2 (50%)
		Ig strand E	202..208	CDD:409562	0/5 (0%)
		Ig strand F	215..222	CDD:409562	3/6 (50%)
		Ig strand G	229..237	CDD:409562	2/7 (29%)
		IG_like	252..335	CDD:214653	24/86 (28%)
		Ig strand B	258..262	CDD:409353	2/3 (67%)
		Ig strand C	271..282	CDD:409353	1/10 (10%)
		Ig strand E	301..306	CDD:409353	1/4 (25%)
		Ig strand F	316..321	CDD:409353	2/4 (50%)
		Ig strand G	329..332	CDD:409353	0/2 (0%)
NTM	NP_001338930.1	Ig	44..132	CDD:472250	26/91 (29%)
		Ig strand B	53..57	CDD:409353	2/3 (67%)
		Ig strand C	65..69	CDD:409353	2/3 (67%)
		Ig strand E	98..102	CDD:409353	0/3 (0%)
		Ig strand F	112..117	CDD:409353	2/4 (50%)
		Ig strand G	125..128	CDD:409353	1/2 (50%)
		Ig_3	136..205	CDD:464046	28/77 (36%)
		Ig	223..307	CDD:472250	26/93 (28%)
		Ig strand B	239..243	CDD:409353	2/3 (67%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)