DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and NTM

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001338930.1	Gene:	NTM / 50863	HGNCID:	17941	Length:	367	Species:	Homo sapiens

Alignment Length:	340	Identity:	100/340 - (29%)
Similarity:	164/340 - (48%)	Gaps:	50/340 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHK 106
            |..|...:.|:|...|..|.|.|.: |....:||||  :..|||...|.....:.|:.:.::...
Human    35 DATFPKAMDNVTVRQGESATLRCTI-DNRVTRVAWL--NRSTILYAGNDKWCLDPRVVLLSNTQT 96

  Fly   107 TWTMRIKDIKESDKGWYMCQINTD--PMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCA 169
            .:::.|:::...|:|.|.|.:.||  |..|:: :|.|.|.|.|::  .|:|:.:.||:|::|.|.
Human    97 QYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRV-HLIVQVSPKIVE--ISSDISINEGNNISLTCI 158

  Fly   170 ATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRIT 234
            |||.||||:|||..|...:...:.:|.:.|:|       :.|...|.|.|.|||.|...|.:|:.
Human   159 ATGRPEPTVTWRHISPKAVGFVSEDEYLEIQG-------ITREQSGDYECSASNDVAAPVVRRVK 216

  Fly   235 LVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYR 299
            :.|::||.|: :.:..|...|:..||.||:.|.|.:...|.::...::.  ||....|      .
Human   217 VTVNYPPYIS-EAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIE--GKKGVKV------E 272

  Fly   300 N----SMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRI---------------------PP 339
            |    |..:..| :::.::|:|.|||.|.||.|:.:|.|:.:                     .|
Human   273 NRPFLSKLIFFN-VSEHDYGNYTCVASNKLGHTNASIMLFELNEPTSSTLLQEVKTTALTPWKGP 336

  Fly   340 NAVNYVENFEARHKG 354
            .||:.|.|..:|..|
Human   337 GAVSEVSNGTSRRAG 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	26/91 (29%)
		IG_like	51..137	CDD:214653	25/87 (29%)
		IG_like	153..237	CDD:214653	31/83 (37%)
		Ig	161..224	CDD:299845	24/62 (39%)
		IG_like	252..335	CDD:214653	24/86 (28%)
		Ig	258..333	CDD:143165	22/78 (28%)
NTM	NP_001338930.1	Ig	44..132	CDD:416386	26/91 (29%)
		Ig strand A'	44..49	CDD:409353	2/4 (50%)
		Ig strand B	51..59	CDD:409353	3/7 (43%)
		CDR1	59..63	CDD:409353	1/4 (25%)
		FR2	64..70	CDD:409353	4/7 (57%)
		Ig strand C	64..70	CDD:409353	4/7 (57%)
		CDR2	71..83	CDD:409353	4/11 (36%)
		Ig strand C'	72..76	CDD:409353	2/3 (67%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	6/33 (18%)
		Ig strand D	87..94	CDD:409353	1/6 (17%)
		Ig strand E	97..103	CDD:409353	0/5 (0%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	2/3 (67%)
		Ig strand G	123..132	CDD:409353	3/9 (33%)
		FR4	125..132	CDD:409353	2/7 (29%)
		Ig_3	136..205	CDD:404760	28/77 (36%)
		Ig strand A'	142..147	CDD:409353	2/4 (50%)
		Ig strand B	153..160	CDD:409353	2/6 (33%)
		Ig strand C	166..171	CDD:409353	3/4 (75%)
		Ig strand D	177..180	CDD:409353	0/2 (0%)
		Ig strand E	184..190	CDD:409353	2/5 (40%)
		Ig strand F	197..204	CDD:409353	3/6 (50%)
		Ig strand G	211..219	CDD:409353	2/7 (29%)
		Ig_3	222..299	CDD:404760	23/86 (27%)
		putative Ig strand A	223..229	CDD:409353	2/6 (33%)
		Ig strand B	239..243	CDD:409353	2/3 (67%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143471
Domainoid	1	1.000	59	1.000	Domainoid score	I10656
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	1	0.900	-	-		OOG6_104123
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.700