DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and NCAM2

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	301	Identity:	80/301 - (26%)
Similarity:	129/301 - (42%)	Gaps:	21/301 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKN 95
            |...|..|:.....|...:.......|.||.:.|.|.......|:|| ...:.:.||.:     |
Human   128 QEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWL-YHNEEVTTISD-----N 186

  Fly    96 QRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVV----VPPDILDYPTSTDM 156
            :...:||:     .::|.:|.:||:|.|.|:...: .:.::.:.|::    |||.|.....|.:.
Human   187 RFAMLANN-----NLQILNINKSDEGIYRCEGRVE-ARGEIDFRDIIVIVNVPPAISMPQKSFNA 245

  Fly   157 VVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIA 221
            ....|..:|..|.|:|||||.|:|.| :|..|| ...:.::....|:|.:.|:.....|.|:|.|
Human   246 TAERGEEMTFSCRASGSPEPAISWFR-NGKLIE-ENEKYILKGSNTELTVRNIINSDGGPYVCRA 308

  Fly   222 SNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRE-RGEIVPPG 285
            :|.......:....|...|.:|.::|:.  ..|...|||.|::|..|.....|.|. .|.....|
Human   309 TNKAGEDEKQAFLQVFVQPHIIQLKNET--TYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEG 371

  Fly   286 GKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLG 326
            .|......|:.|...|..|||..:..::.|.|.|.|.:.:|
Human   372 DKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	20/89 (22%)
		IG_like	51..137	CDD:214653	20/85 (24%)
		IG_like	153..237	CDD:214653	24/83 (29%)
		Ig	161..224	CDD:299845	22/62 (35%)
		IG_like	252..335	CDD:214653	23/76 (30%)
		Ig	258..333	CDD:143165	22/70 (31%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	3/8 (38%)
		I-set	47..136	CDD:254352	2/7 (29%)
		I-set	142..218	CDD:254352	21/87 (24%)
		IGc2	153..214	CDD:197706	20/71 (28%)
		Ig	233..326	CDD:299845	28/94 (30%)
		I-set	240..323	CDD:254352	24/84 (29%)
		Ig5_NCAM-2	325..422	CDD:143278	26/90 (29%)
		IG_like	333..420	CDD:214653	24/82 (29%)
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910