DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and NCAM1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	369	Identity:	95/369 - (25%)
Similarity:	147/369 - (39%)	Gaps:	77/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AEVIVDPKFSSPIVNMTAPV------GRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKN 95
            :|..|:.|....::...||.      |.||.:.|.|....|..:.|.......||       .|:
Human   106 SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL-------KKD 163

  Fly    96 QRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLD----VVVPPDILDYPTSTDM 156
            .|..:.::.:    ::|:.||::|:|.|.|: .....:.::.:.|    |.|||.|.......:.
Human   164 VRFIVLSNNY----LQIRGIKKTDEGTYRCE-GRILARGEINFKDIQVIVNVPPTIQARQNIVNA 223

  Fly   157 VVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEE--VMSIEGTDLVIPNVRRHHMGAYLC 219
            ....|.:|||.|.|.|.||||::|.:: |..||....:|  :.|.:.:.|.|..|.::....|:|
Human   224 TANLGQSVTLVCDAEGFPEPTMSWTKD-GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287

  Fly   220 IASNGVPPSVSKRITLVVHFPPMIT-VQNQLIGAVEGKGVTLDCESEAYP-KSINY--------- 273
            ||.|..... ...|.|.|...|.|| |:||....:| :.|||.||:...| .||.:
Human   288 IAENKAGEQ-DATIHLKVFAKPKITYVENQTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISS 350

  Fly   274 -----WTR-ERGEIVPPG----GKYSANVTEIG---------GY---RNSMR---LHINPLTQAE 313
                 ||| |:.|:..|.    |:........|         |:   |:..|   |.:..:...:
Human   351 EEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTD 415

  Fly   314 FGSYRCVAKNSLGD--------------TDGTIKLYRIPPNAVN 343
            .|.|.|.|.|::|.              ..|.:.:|....|.||
Human   416 AGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVN 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/99 (21%)
		IG_like	51..137	CDD:214653	20/91 (22%)
		IG_like	153..237	CDD:214653	27/85 (32%)
		Ig	161..224	CDD:299845	24/64 (38%)
		IG_like	252..335	CDD:214653	28/131 (21%)
		Ig	258..333	CDD:143165	27/123 (22%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	3/8 (38%)
		IG	124..190	CDD:214652	18/76 (24%)
		Ig	211..307	CDD:325142	31/97 (32%)
		Ig	306..438	CDD:325142	33/132 (25%)
		Ig_3	447..519	CDD:316449	4/13 (31%)
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910