DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and LSAMP

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	373	Identity:	113/373 - (30%)
Similarity:	167/373 - (44%)	Gaps:	77/373 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 MSQQCYPQRVEVPAEVI--------------VDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKV 74
            |.::..|.|.::|..::              ||  |:....|:|...|..|.|.|||:|... ||
Human     1 MVRRVQPDRKQLPLVLLRLLCLLPTGLPVRSVD--FNRGTDNITVRQGDTAILRCVVEDKNS-KV 62

  Fly    75 AWLRVDTQTILTIQNHVITKNQRIGIANSEHKTW----------------TMRIKDIKESDKGWY 123
            |||                  .|.||..:.|..|                ::||:.:...|:|.|
Human    63 AWL------------------NRSGIIFAGHDKWSLDPRVELEKRHSLEYSLRIQKVDVYDEGSY 109

  Fly   124 MCQINT--DPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGV 186
            .|.:.|  :|..||: ||.|.|||.|.:  .|:|:.|.|||||||.|.|.|.|||.||||..:..
Human   110 TCSVQTQHEPKTSQV-YLIVQVPPKISN--ISSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPT 171

  Fly   187 PIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIG 251
            ..|....||.:.|.|       :.|...|.|.|.|:|.|..:..|::.:.|::||.|| :::...
Human   172 GREFEGEEEYLEILG-------ITREQSGKYECKAANEVSSADVKQVKVTVNYPPTIT-ESKSNE 228

  Fly   252 AVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGS 316
            |..|:..:|.||:.|.|.....|.|:...|      .|||..||........|.:..:|:..:|:
Human   229 ATTGRQASLKCEASAVPAPDFEWYRDDTRI------NSANGLEIKSTEGQSSLTVTNVTEEHYGN 287

  Fly   317 YRCVAKNSLGDTDGTIKLY-RIPPNAVNYVE------NFEARHKGKKR 357
            |.|||.|.||.|:.::.|: |:.|...:.::      :|:.:..|..|
Human   288 YTCVAANKLGVTNASLVLFKRVLPTIPHPIQEIGTTVHFKQKGPGSVR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	31/107 (29%)
		IG_like	51..137	CDD:214653	29/103 (28%)
		IG_like	153..237	CDD:214653	33/83 (40%)
		Ig	161..224	CDD:299845	26/62 (42%)
		IG_like	252..335	CDD:214653	26/82 (32%)
		Ig	258..333	CDD:143165	24/74 (32%)
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	31/109 (28%)
		Ig	132..215	CDD:386229	35/91 (38%)
		Ig_3	219..294	CDD:372822	25/81 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143416
Domainoid	1	1.000	59	1.000	Domainoid score	I10656
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.800