DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and Sdk2

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	76/342 - (22%)
Similarity:	131/342 - (38%)	Gaps:	54/342 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QRVEVPAE-----VIVDPKFSSPIVNMTAPVGRDAFLTCV--VQDLGPYKVAWLRVDTQTILTIQ 88
            :.|..||:     :|:.||.:|.:...:     :..:.||  .:.|....:.|.:...    .:.
  Rat   207 ENVGGPADPIAPTIIIPPKNTSVVAGTS-----EVTMECVANARPLIKLHIVWKKDGA----LLS 262

  Fly    89 NHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQI-----NTDPMKSQMGYLDVVVPPDIL 148
            |.:...|:|:.|.|.            ..||.|:|.|:.     :..|: ::..||.|:.||..:
  Rat   263 NGISDYNRRLTITNP------------MVSDAGYYECEAMLRSSSVAPV-TRGAYLSVLEPPQFV 314

  Fly   149 DYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHH 213
            ..| ...:.......|.:.|.|.|.|.|:|||.:::.: :|:.............|.|..:....
  Rat   315 REP-ERHITAEMEKVVDIPCRAKGVPPPSITWYKDAAL-VEVGKLTRFKQRSDGGLQISGLLPDD 377

  Fly   214 MGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRER 278
            .|...|.|.|....:.:.....|....|.||........::|..|.|.||:...|:....|  ::
  Rat   378 TGMVQCFAHNAAGEAQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITW--QK 440

  Fly   279 GEIVPPGGKYSA---NVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLY----- 335
            ||.:...|....   .:.|.|.      |.|:|...::.|:|.|:|.||.|..:.:..|.
  Rat   441 GERILASGSVQLPRFTLLESGS------LLISPTHISDAGTYTCLATNSRGVDEASADLVVWART 499

  Fly   336 RI--PPNAVNYVENFEA 350
            ||  ||...:.::..:|
  Rat   500 RITKPPQDQSVIKGTQA 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	17/96 (18%)
		IG_like	51..137	CDD:214653	15/92 (16%)
		IG_like	153..237	CDD:214653	16/83 (19%)
		Ig	161..224	CDD:299845	15/62 (24%)
		IG_like	252..335	CDD:214653	22/85 (26%)
		Ig	258..333	CDD:143165	21/77 (27%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653
		Ig	135..191	CDD:299845
		IG_like	225..307	CDD:214653	19/103 (18%)
		IGc2	236..289	CDD:197706	14/68 (21%)
		I-set	311..400	CDD:254352	18/90 (20%)
		Ig	329..397	CDD:143165	16/68 (24%)
		I-set	405..495	CDD:254352	26/97 (27%)
		Ig	419..495	CDD:299845	23/83 (28%)
		Ig	505..589	CDD:299845	2/12 (17%)
		IG_like	505..589	CDD:214653	2/12 (17%)
		FN3	593..684	CDD:238020
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810