DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and itgb4

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	357	Identity:	70/357 - (19%)
Similarity:	119/357 - (33%)	Gaps:	130/357 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKN 95
            |.|:||..:              |.:|:|           ...:..|:....::.|......|.:
Zfish   964 QAVDVPVGI--------------AKIGKD-----------HVNITVLKEQASSVFTFLEPSYTYS 1003

  Fly    96 QRIGIANSEHKTW---------TMRIKDIKESDKGWYMCQINTD------------PMK-----S 134
            ::.|:||...|..         |....|:...||..|: .::.|            |:|     .
Zfish  1004 RQDGVANIPIKRQIIEDGRAQVTYSTADLTAKDKKDYI-SVDGDLSYGAGETEKIVPVKLLELGE 1067

  Fly   135 QMGYL----------DVVVPPD-------------ILDYPTSTDMVVREGSNV--------TLKC 168
            |.|.|          |:..|..             |.|.|.|:.|..::.:..        |:..
Zfish  1068 QDGLLEDKQVKQFVMDLTNPRQSAKLGRYPRTVITIADKPESSVMAFKKSTQTFSTTDSLYTIPV 1132

  Fly   169 AATGSPE--PTITWRR------ESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGV 225
            ..||:.|  .|:.||.      :...|::.|.||...:|      :.|.|.|            .
Zfish  1133 ERTGNRETPATVHWRTNKASRFDISSPLKFAPGEAEKNI------LINPRTH------------P 1179

  Fly   226 PPSVSKRITLVVHFPPMITVQNQLIG--------AVEGKGVTLDCESEAYPKSINYWTRERGEIV 282
            .|.:.::..|.:..|.    .|.:||        ..:|:|   |.:::.:.| :.|.|:   ...
Zfish  1180 SPIIPEKFNLELLDPS----NNAIIGKRKTTEVIVTDGRG---DGKNQDFQK-MEYVTQ---TAT 1233

  Fly   283 PPGGK-YS-ANVTEIGGYRNSMRLHINPLTQA 312
            .|||: || ||:..:.....::||:..|...|
Zfish  1234 SPGGRLYSPANIKAVATGPKNIRLNWKPSQNA 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/125 (17%)
		IG_like	51..137	CDD:214653	19/111 (17%)
		IG_like	153..237	CDD:214653	19/99 (19%)
		Ig	161..224	CDD:299845	15/78 (19%)
		IG_like	252..335	CDD:214653	17/63 (27%)
		Ig	258..333	CDD:143165	15/57 (26%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344	14/73 (19%)
		FN3	1242..1326	CDD:238020	6/24 (25%)
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900