DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and Nrg

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	271	Identity:	73/271 - (26%)
Similarity:	116/271 - (42%)	Gaps:	25/271 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 QTILTIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVVVPPD 146
            ||:.:.....|..:.||   ...|...::.|:.....|.|.|.|.::.....:|.  ..:::..:
  Fly   277 QTVWSKDGQRIQWSDRI---TQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQS--FSIILNVN 336

  Fly   147 ILDYPTSTDMV--VREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNV 209
            .:.|.|....:  ..|...|..:|.|.|.|||.|:| ..:|.|||.:|.....::....:.|.|:
  Fly   337 SVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISW-IHNGKPIEQSTPNPRRTVTDNTIRIINL 400

  Fly   210 RRHHMGAYLCIASNGVPPSVSKRITLVVHF-PPMITVQNQLIGAVEGKGVTLDCESEAYPKSINY 273
            .:...|.|.|.|:|.: ..|.|.:.|.|.. ||.|:.....:..|:|:.||:.|.....||.:..
  Fly   401 VKGDTGNYGCNATNSL-GYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVK 464

  Fly   274 WTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGD--TDGTIKL-- 334
            |.|....:.  ||:|  ||...|.      |.|..:|.::.|.|.|.|:|..|:  .||::.:
  Fly   465 WLRASNWLT--GGRY--NVQANGD------LEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKE 519

  Fly   335 -YRIPPNAVNY 344
             .||.....||
  Fly   520 HTRITQEPQNY 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	12/58 (21%)
		IG_like	51..137	CDD:214653	12/54 (22%)
		IG_like	153..237	CDD:214653	25/85 (29%)
		Ig	161..224	CDD:299845	20/62 (32%)
		IG_like	252..335	CDD:214653	26/87 (30%)
		Ig	258..333	CDD:143165	24/76 (32%)
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	12/59 (20%)
		I-set	339..427	CDD:254352	27/89 (30%)
		Ig	354..427	CDD:299845	24/74 (32%)
		I-set	432..517	CDD:254352	28/94 (30%)
		Ig	446..517	CDD:299845	25/80 (31%)
		I-set	522..611	CDD:254352	4/9 (44%)
		ig	525..609	CDD:278476	2/6 (33%)
		FN3	613..707	CDD:238020
		FN3	716..807	CDD:238020
		fn3	817..905	CDD:278470
		FN3	917..1004	CDD:238020
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010