DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and Prtg

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001032740.2	Gene:	Prtg / 315806	RGDID:	1307157	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	101/435 - (23%)
Similarity:	171/435 - (39%)	Gaps:	78/435 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVILLLILMSQQCYPQRVEVP-----AEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKV 74
            |.::|||:|      |....||     :|:....:.....|....||    ||.|.....||.||
  Rat    10 LPLLLLLLL------PPLGSVPGVWSFSELFFMKEPQDATVTRKDPV----FLDCQAHGEGPIKV 64

  Fly    75 AWLRVDTQTILTIQNHVITKNQRIGIANSEHKTWTMRIKDI-----KESDKGWYMC-QINT-DPM 132
            .||:...:         :::|:||.:.::    .::.|.:.     ::||:|:|.| .:|. ..:
  Rat    65 TWLKNGAK---------LSENKRIQVLSN----GSLYISEAEGRRGEQSDEGFYQCLAVNKYGAI 116

  Fly   133 KSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWR-RESGVPIELATGEEV 196
            .||..:|.:........:|.||:  |.||......|..:.:|...|||. ..:.:|:.:  ...|
  Rat   117 LSQKAHLTLSTISAFEVHPVSTE--VPEGGVARFSCKISSTPPAVITWEFNRTALPMTM--DSRV 177

  Fly   197 MSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVV--------HFPPMITVQNQLIGAV 253
            .::....|.|.:......|.|.|:|:.......|...:|.:        .:.|.|....|.:.|.
  Rat   178 TALPSGVLQIYDAGPEDAGKYRCVAATHAHKRKSMEASLTIVPANETRSFYMPTIIASPQNVTAS 242

  Fly   254 EGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANV--TEIGGYRNSMRLHINPLTQAEFGS 316
            ..:.|.|:|.:..|||.|..|:|...:        |.:|  |.:.|..|   |.|:.:.....|.
  Rat   243 LHQTVVLECMATGYPKPIISWSRLDHK--------SIDVFNTRVLGNGN---LIISDVKLQHAGV 296

  Fly   317 YRCVAKNSLGDTDGTIKLYRI----PPNAVNYVENFEARHKGKKR--TKSSESHHPARAQEHSGE 375
            |.|.| .:.|..:.|:.:..:    ||:.|.:.|:......|..|  .::.....|..:...:|.
  Rat   297 YVCRA-TTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGR 360

  Fly   376 DMENPGKRKA-DLSLGAESI----DSIYGNSAAGSRRRQDLGGVL 415
            .:.:.|:.|. :..|....|    |:||...|..|:     |.||
  Rat   361 RIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQ-----GSVL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	24/96 (25%)
		IG_like	51..137	CDD:214653	23/92 (25%)
		IG_like	153..237	CDD:214653	20/84 (24%)
		Ig	161..224	CDD:299845	14/63 (22%)
		IG_like	252..335	CDD:214653	23/84 (27%)
		Ig	258..333	CDD:143165	22/76 (29%)
Prtg	NP_001032740.2	Ig	32..124	CDD:416386	25/108 (23%)
		Ig strand A	32..35	CDD:409353	1/2 (50%)
		Ig strand A'	38..44	CDD:409353	0/5 (0%)
		Ig strand B	48..58	CDD:409353	5/13 (38%)
		Ig strand C	62..68	CDD:409353	3/5 (60%)
		Ig strand C'	70..73	CDD:409353	0/11 (0%)
		Ig strand D	78..83	CDD:409353	2/4 (50%)
		Ig strand E	85..91	CDD:409353	1/5 (20%)
		Ig strand F	103..110	CDD:409353	3/6 (50%)
		Ig strand G	114..124	CDD:409353	2/9 (22%)
		Ig	131..218	CDD:416386	21/90 (23%)
		Ig strand B	146..150	CDD:409353	0/3 (0%)
		Ig strand C	159..163	CDD:409353	2/3 (67%)
		Ig strand E	183..187	CDD:409353	1/3 (33%)
		Ig strand F	197..202	CDD:409353	2/4 (50%)
		Ig strand G	211..214	CDD:409353	1/2 (50%)
		Ig_3	230..302	CDD:404760	24/83 (29%)
		Ig strand B	247..251	CDD:409353	2/3 (67%)
		Ig strand C	260..264	CDD:409353	1/3 (33%)
		Ig strand E	282..286	CDD:409353	2/6 (33%)
		Ig strand F	296..301	CDD:409353	2/4 (50%)
		I-set	322..407	CDD:400151	19/84 (23%)
		Ig strand C	352..357	CDD:409353	0/4 (0%)
		Ig strand C'	359..362	CDD:409353	1/2 (50%)
		Ig strand D	367..371	CDD:409353	1/3 (33%)
		Ig strand E	373..378	CDD:409353	1/4 (25%)
		Ig strand F	387..394	CDD:409353	3/6 (50%)
		Ig strand G	398..407	CDD:409353	2/3 (67%)
		FN3	414..507	CDD:238020
		FN3	512..605	CDD:238020
		fn3	619..694	CDD:394996
		FN3	721..809	CDD:238020
		FN3	816..906	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100