DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and Vsig10

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001258265.1	Gene:	Vsig10 / 304529	RGDID:	1565800	Length:	564	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	96/476 - (20%)
Similarity:	168/476 - (35%)	Gaps:	134/476 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VAWLRVDTQTILTIQNHVITKNQRIGIAN---SEHKTWTMRIKDIKESDKGWYMCQ--INTD--- 130
            |.|.|.|::...     :::.|..:..|.   |......:||:.::..|.|.|.|:  :|..
  Rat    80 VTWYRNDSEPAF-----LVSSNSSLPPAAPRFSLEDAGALRIEALRLEDDGNYTCREVLNETHWF 139

  Fly   131 PMKSQMGYLDVVVPPDILD--------YPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVP 187
            |::     |.|...|..:|        .|..| :....||.|...|.:...|.|.:.|..::...
  Rat   140 PVQ-----LRVTSGPAHIDVNISATGTLPNGT-LYAARGSQVDFSCCSAAQPPPEVEWWIQTHSS 198

  Fly   188 IELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRIT--LVVHFPPMITVQNQLI 250
            :..:.|:   ::......:..:.::..|.|.|.|:| |.....:::|  |:|::||....|....
  Rat   199 VSESLGK---NLSANSFTLMLMSKNLQGNYTCSATN-VLSRRQRKVTTELLVYWPPPSAPQCSAG 259

  Fly   251 GAVEGKGVTLDCESE-AYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEF 314
            .:.|...:.|.|..: .||.....||.|.|.:|            :|   ||....::|...:|.
  Rat   260 LSPESANLELTCNWDGGYPDPTFLWTEEPGGVV------------VG---NSKLQTLSPSQLSEG 309

  Fly   315 GSYRCVAKNSLGDTDGTIKLYRI-----------------------------PPNAVNYVENF-- 348
            ..::||..:.||...|...:.:|                             ||..:.::.|.
  Rat   310 KKFKCVGSHILGPESGASCVVQISSPLLASRPMKTCLVGGDVTLTCQVEGANPPARIQWLRNLTQ 374

  Fly   349 -------EARHKGKKRTKSSESHHPARAQEHSGE----DMENP-GKRKADLSLGAE---SIDSIY 398
                   .:|:...::.:||.......:|:..|.    ..||| |.|.||:.|..:   ::..|.
  Rat   375 PETAIQPSSRYVITQQGQSSSLTIHNCSQDQDGGFYFCRAENPVGVRAADIWLSVKEPLNVGGIV 439

  Fly   399 GN-------------------------SAAGSRRRQDLGGVLLLL----------LPVAVAVAMS 428
            |.                         .|..:.|.||:|.|::|:          ...|:|..:.
  Rat   440 GTVVSLLLLGLAIVSGLMLYYSPAFCWKAGSTLRGQDMGDVMVLVDSEEEEEEEENKGALAEVVG 504

  Fly   429 LATAGVMRETQMTLPPQTLTH 449
            ..|    |||:..||.:...|
  Rat   505 QET----RETEEELPKEIGKH 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	16/74 (22%)
		IG_like	51..137	CDD:214653	15/70 (21%)
		IG_like	153..237	CDD:214653	17/85 (20%)
		Ig	161..224	CDD:299845	12/62 (19%)
		IG_like	252..335	CDD:214653	20/83 (24%)
		Ig	258..333	CDD:143165	19/75 (25%)
Vsig10	NP_001258265.1	Ig	60..146	CDD:299845	16/75 (21%)
		IG_like	60..145	CDD:214653	16/74 (22%)
		IG_like	165..246	CDD:214653	17/85 (20%)
		Ig	175..241	CDD:143165	12/69 (17%)
		Ig_3	255..318	CDD:290638	18/77 (23%)
		IG_like	347..429	CDD:214653	16/81 (20%)
		Ig	351..426	CDD:143165	15/74 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100