DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and NEGR1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	348	Identity:	110/348 - (31%)
Similarity:	159/348 - (45%)	Gaps:	50/348 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CRKQTCALSVILLLILMSQQCYP--QRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLG 70
            |..|..| :|:|.|..:...|.|  |.|:.|         .:.:.||....|..|.|.|.::| |
Human    12 CSNQWLA-AVLLSLCCLLPSCLPAGQSVDFP---------WAAVDNMMVRKGDTAVLRCYLED-G 65

  Fly    71 PYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTD--PMK 133
            ..|.|||  :..:|:.......:.:.|:.|:....:.::::|:::..:|.|.|.|.:.|.  |..
Human    66 ASKGAWL--NRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRT 128

  Fly   134 SQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRR--ESGVPIELATGEEV 196
            .|: :|.|.|||.|  |..|.||.|.||:||||.|.|||.|||:|:||.  .|..|.|
Human   129 MQV-HLTVQVPPKI--YDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFE------- 183

  Fly   197 MSIEGTDLVIPNVRRHHMGAYLCIASNGVP-PSVSKRITLVVHFPPMITVQNQLIGAV-EGKGVT 259
               .|..|.|..:.|...|.|.|.|.|.|. |.| :::.:||:|.|  |:|....|.| .|:...
Human   184 ---NGQYLDIYGITRDQAGEYECSAENDVSFPDV-RKVKVVVNFAP--TIQEIKSGTVTPGRSGL 242

  Fly   260 LDCESEAYPKSINYWTRERGEIVPPGGKYSANVTE---IGGYRNSMRLHINPLTQAEFGSYRCVA 321
            :.||....|.....|.:        |.|...|..:   |..:.....|.:..:||..||:|.|||
Human   243 IRCEGAGVPPPAFEWYK--------GEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVA 299

  Fly   322 KNSLGDTDGTIKLYRIPPNAVNY 344
            .|.||.|:.::.|.  ||:...|
Human   300 ANKLGTTNASLPLN--PPSTAQY 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	24/91 (26%)
		IG_like	51..137	CDD:214653	23/87 (26%)
		IG_like	153..237	CDD:214653	35/86 (41%)
		Ig	161..224	CDD:299845	26/64 (41%)
		IG_like	252..335	CDD:214653	23/86 (27%)
		Ig	258..333	CDD:143165	21/77 (27%)
NEGR1	NP_776169.2	IG	47..135	CDD:214652	24/91 (26%)
		IGc2	152..210	CDD:197706	28/67 (42%)
		Ig_3	225..301	CDD:372822	23/85 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143461
Domainoid	1	1.000	59	1.000	Domainoid score	I10656
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750