DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and Ncam1

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	116/568 - (20%)
Similarity:	191/568 - (33%)	Gaps:	219/568 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AEVIVDPKFSSPIVNMTAPV------GRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKN 95
            :|..|:.|....::...||.      |.||.:.|.|....|..:.|.......||       .|:
  Rat   106 SEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVIL-------KKD 163

  Fly    96 QRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLD----VVVPPDILDYPTSTDM 156
            .|..:.::.:    ::|:.||::|:|.|.|: .....:.::.:.|    |.|||.:....:..:.
  Rat   164 VRFIVLSNNY----LQIRGIKKTDEGTYRCE-GRILARGEINFKDIQVIVNVPPTVQARQSIVNA 223

  Fly   157 VVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEE------VMSIEGTDLVIPNVRRHHMG 215
            ....|.:|||.|.|.|.||||::|.:: |.|||   .||      :.|.:.::|.|.||.::...
  Rat   224 TANLGQSVTLVCDADGFPEPTMSWTKD-GEPIE---NEEEDDEKHIFSDDSSELTIRNVDKNDEA 284

  Fly   216 AYLCIASN-----------------------------------------GVP-PSVS-------- 230
            .|:|||.|                                         |.| ||::
  Rat   285 EYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI 349

  Fly   231 ------------KRITLVVHF----------------------PPMITVQN-------------- 247
                        |:.||..|.                      ..:.|..|
  Rat   350 SSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 414

  Fly   248 ---QLIGAV-----EGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYR--NSM 302
               :|.|.|     ||..|.:.||..|||.:...|.|: |:::|     |:|.:.|..|.  ::.
  Rat   415 YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD-GQLLP-----SSNYSNIKIYNTPSAS 473

  Fly   303 RLHINPLTQAEFGSYRCVAKNSLG-----------DTDGTIKLYRIPPNAVNYVENFE------- 349
            .|.:.|.::.:||:|.|.|.|.:|           ||..:..:.|:.|.:......|:
  Rat   474 YLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDEPEATGG 538

  Fly   350 ---ARHKGKKRTKSSESHHP----------------------------------------ARAQE 371
               .::|.:.::...|:.|.                                        :.|.|
  Rat   539 VPILKYKAEWKSLGEEAWHSKWYDAKEANMEGIVTIMGLKPETRYAVRLAALNGKGLGEISAATE 603

  Fly   372 ------HSGEDMENPGKRKADLSLGAESIDSIYGNSAAGSRRRQDLGG 413
                  ||......|...|.:..:|.:      |||...:..:||.||
  Rat   604 FKTQPVHSPPPQGEPSAPKLEGQMGED------GNSIKVNLIKQDDGG 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/99 (21%)
		IG_like	51..137	CDD:214653	20/91 (22%)
		IG_like	153..237	CDD:214653	35/151 (23%)
		Ig	161..224	CDD:299845	28/109 (26%)
		IG_like	252..335	CDD:214653	28/100 (28%)
		Ig	258..333	CDD:143165	25/87 (29%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451	3/9 (33%)
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451
		Ig strand F	93..98	CDD:409451
		Ig strand G	107..110	CDD:409451	1/2 (50%)
		IG_like	124..190	CDD:214653	18/76 (24%)
		Ig strand B	135..139	CDD:409353	1/3 (33%)
		Ig strand C	148..152	CDD:409353	0/3 (0%)
		Ig strand E	172..176	CDD:409353	0/7 (0%)
		Ig strand F	186..191	CDD:409353	2/5 (40%)
		IgI_3_NCAM-1	211..308	CDD:143207	30/100 (30%)
		Ig strand B	231..235	CDD:143207	3/3 (100%)
		Ig strand C	244..248	CDD:143207	1/3 (33%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	2/4 (50%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	10/105 (10%)
		Ig strand B	326..330	CDD:143277	0/3 (0%)
		Ig strand C	339..343	CDD:143277	1/3 (33%)
		Ig strand E	379..383	CDD:143277	0/3 (0%)
		Ig strand F	393..398	CDD:143277	0/4 (0%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	24/77 (31%)
		Ig strand B	433..437	CDD:409353	1/3 (33%)
		Ig strand C	446..450	CDD:409353	0/3 (0%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	10/96 (10%)
		fn3	619..701	CDD:394996	9/33 (27%)
		Herpes_BLLF1	<842..1133	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910