DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and Vsig10

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001028483.2	Gene:	Vsig10 / 231668	MGIID:	2448533	Length:	558	Species:	Mus musculus

Alignment Length:	416	Identity:	85/416 - (20%)
Similarity:	156/416 - (37%)	Gaps:	100/416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VAWLRVDTQT--ILTIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQ--INTD---P 131
            |.|.|.|::.  :::..:.:.....|..:.::    ..:||:.::..|.|.|.||  :|..   |
Mouse    75 VTWYRNDSEPAFLVSFNSSLPPAAPRFSLEDA----GALRIEALRLEDDGNYTCQEVLNETHWFP 135

  Fly   132 MK----SQMGYLDVVVPPDILDYPTST----DMVVREGSNVTLKCAATGSPEPTITWRRES-GVP 187
            ::    |...|::|.:.      .|.|    .:....||.|...|.:...|.|.:.|..:: .:|
Mouse   136 VRLRVASGPAYVEVNIS------ATGTLPNGTLYAARGSQVDFNCCSAAQPPPEVEWWIQTHSIP 194

  Fly   188 IELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRIT--LVVHFPPMITVQNQLI 250
            ..|.     .::......:..:.::..|.|.|.|:| |.....:::|  |:|::||....|..:.
Mouse   195 EFLG-----KNLSANSFTLMLMSQNLQGNYTCSATN-VLSGRQRKVTTELLVYWPPPSAPQCSVE 253

  Fly   251 GAVEGKGVTLDCESE-AYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEF 314
            .:.|...:.|.|..: .||.....||.|      |||      |.:|   ||....::|....|.
Mouse   254 VSSESTTLELACNWDGGYPDPTFLWTEE------PGG------TIMG---NSKLQTLSPAQLLEG 303

  Fly   315 GSYRCVAKNSLGDTDGTIKLYRI-----------------------------PPNAVNYVENFEA 350
            ..::||..:.||...|...:.::                             ||..:.::.|.
Mouse   304 KKFKCVGNHILGPESGASCVVKLSSPLLPSQPMRTCFVGGNVTLTCEVSGANPPARIQWLRNL-- 366

  Fly   351 RHKGKKRTKSSESHHPARAQ-EHSGEDMENPGKRKADLSLG-----AESIDSIYG-NSAAGSRRR 408
                .:......||:....| :.|...:.|..:   ||..|     ||::..:.. |.....:..
Mouse   367 ----TQPAIQPSSHYIITQQGQSSSLTIHNCSQ---DLDEGFYYCQAENLVGVRATNIWLSVKEP 424

  Fly   409 QDLGGVL-----LLLLPVAVAVAMSL 429
            .::||::     ||||.:||...::|
Mouse   425 LNIGGIVGTVVSLLLLGLAVVSGLTL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	16/77 (21%)
		IG_like	51..137	CDD:214653	15/73 (21%)
		IG_like	153..237	CDD:214653	18/90 (20%)
		Ig	161..224	CDD:299845	13/63 (21%)
		IG_like	252..335	CDD:214653	22/83 (27%)
		Ig	258..333	CDD:143165	21/75 (28%)
Vsig10	NP_001028483.2	Ig	47..135	CDD:299845	13/63 (21%)
		IG_like	55..140	CDD:214653	14/68 (21%)
		IG_like	160..240	CDD:214653	17/85 (20%)
		Ig	<184..238	CDD:299845	10/59 (17%)
		IG_like	341..421	CDD:214653	14/88 (16%)
		Ig	345..418	CDD:143165	14/81 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..515
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100