DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	342	Identity:	86/342 - (25%)
Similarity:	140/342 - (40%)	Gaps:	72/342 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DPKFSSPIVNMTAPVGRDAFLTC-----VVQDLGPYKVAWLRVDTQTILTIQ-----NHVITKNQ 96
            :|:|      :||..|....|.|     |.....||.|.|.:......:.|:     .||  ..:
Human    29 EPEF------VTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHV--DPE 85

  Fly    97 RIGIANSEHKTWTMRIKDIKESDKGWYMCQI-----NTDPM-KSQMGYLDVVVPPDILDYPTSTD 155
            ..|.| |.|...::|::.::..|:|||.|::     ..|.. .....:|.:..||...:.|...
Human    86 YAGRA-SLHDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQY- 148

  Fly   156 MVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCI 220
            :..:||.::|:.|.|.|:|:|.:||.:|.  .:..|:|:..:| :|: |.:.:|.|...|||.|.
Human   149 IEAKEGGSITMTCTAFGNPKPIVTWLKEG--TLLGASGKYQVS-DGS-LTVTSVSREDRGAYTCR 209

  Fly   221 ASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSIN---YWTRERGEIV 282
            |.: :.........|:|..||.|....:.|.....:...|.|.:||||.::.   ||..|
Human   210 AYS-IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDE----- 268

  Fly   283 PPGGKYSANVTEIGGYRNSMRLHINPLTQA----------EFGSYRCVAKNSLGDTDGT------ 331
                    ||.    ::|.::|.:..|...          :.|.|.||..||||.:...
Human   269 --------NVY----FQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV 321

  Fly   332 ---IKLYRIPPNAVNYV 345
               .::..:||  |.||
Human   322 QYPARVLNMPP--VIYV 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	25/105 (24%)
		IG_like	51..137	CDD:214653	24/101 (24%)
		IG_like	153..237	CDD:214653	24/83 (29%)
		Ig	161..224	CDD:299845	22/62 (35%)
		IG_like	252..335	CDD:214653	22/104 (21%)
		Ig	258..333	CDD:143165	22/96 (23%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	25/93 (27%)
		Ig	41..115	CDD:143165	20/76 (26%)
		I-set	139..225	CDD:254352	26/91 (29%)
		IGc2	153..210	CDD:197706	22/60 (37%)
		I-set	229..321	CDD:254352	25/108 (23%)
		Ig	235..321	CDD:299845	23/102 (23%)
		IG_like	331..414	CDD:214653	5/8 (63%)
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910