DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and sma-10

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	83/369 - (22%)
Similarity:	134/369 - (36%)	Gaps:	86/369 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAW----------LRVDTQTILTIQNHV 91
            |:::..|      |.::..:|..|..||.|....|..:.|          |..|:.|.|:|....
Worm   505 AKIVRQP------VEVSTLIGEKARFTCNVYGASPLSIEWRVMENGQPRVLVQDSATFLSINRTA 563

  Fly    92 I---TKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMG-------YLDVVVPPD 146
            :   |.::| .:|.:|     :.:.::..:|...|.|     ..:::.|       .|.|...|.
Worm   564 VVNGTFDER-ELAAAE-----LLLDNVAMTDNSEYQC-----VARNRFGSDFSTHVKLQVYQAPK 617

  Fly   147 ILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTD-LVIPNVR 210
            ....|  .||.:..|......|||||:|.|.|.|..|. :|...|....:......| :.|.||.
Worm   618 FTYTP--EDMPLLVGQTAKFLCAATGTPRPEIKWAFEQ-IPFPAAEARRLYVTPNDDHIYIMNVT 679

  Fly   211 RHHMGAYLCIASNGVPPSVSKRITLVV-----HFPPMITVQNQLIGAVEGKGVTLDCESEAY-PK 269
            :...|||.|.|:| |.........|:|     |:|....:...||  .:...:.:||..:.. .:
Worm   680 KEDQGAYTCHATN-VAGQTQASANLIVFENFFHYPESPDLSPMLI--KKRDALKIDCSCDLISSR 741

  Fly   270 SINYWTRERGEIV-PPGGKYSANVTEIGGYRNSMRLHINPLTQAEF---GSYRC----------- 319
            ....|.|::..|: ....|:|.|.            .|..|||..|   |.|.|
Worm   742 QRMVWKRQQQVILFLKKAKFSDND------------QILTLTQTTFSDSGEYSCELWVDDTILMR 794

  Fly   320 -------VAKNSLGDTDGTI--KLYRIPPNAVNYVENFEARHKG 354
                   |.::....::.|:  ::.||...|...|:|.::...|
Worm   795 KITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKSTGNG 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	21/109 (19%)
		IG_like	51..137	CDD:214653	19/98 (19%)
		IG_like	153..237	CDD:214653	27/84 (32%)
		Ig	161..224	CDD:299845	22/63 (35%)
		IG_like	252..335	CDD:214653	18/107 (17%)
		Ig	258..333	CDD:143165	18/99 (18%)
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		LRR_8	172..231	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380
		LRR_8	243..303	CDD:290566
		leucine-rich repeat	245..268	CDD:275380
		LRR_RI	269..453	CDD:238064
		leucine-rich repeat	269..292	CDD:275380
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	315..373	CDD:290566
		leucine-rich repeat	317..340	CDD:275380
		leucine-rich repeat	341..364	CDD:275380
		leucine-rich repeat	365..392	CDD:275380
		LRR_8	393..450	CDD:290566
		leucine-rich repeat	393..416	CDD:275380
		leucine-rich repeat	417..438	CDD:275380
		I-set	506..612	CDD:254352	23/122 (19%)
		Ig	522..606	CDD:143165	19/94 (20%)
		I-set	616..705	CDD:254352	29/92 (32%)
		Ig	633..705	CDD:299845	24/73 (33%)
		Ig	716..786	CDD:299845	18/83 (22%)
		IG	719..788	CDD:214652	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000