DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and Papln

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	193	Identity:	50/193 - (25%)
Similarity:	73/193 - (37%)	Gaps:	54/193 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 PDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNV 209
            |.::|        ...|..:.|.|.|.|.|.|||.|:|:..:   :::....:..:|: |||..|
Mouse  1072 PGVVD--------ASPGQRIRLTCRAEGFPVPTIEWQRDGQL---VSSPRHQVQPDGS-LVISRV 1124

  Fly   210 RRHHMGAYLCIASNG-------VPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAY 267
            .....|.|.|:|.||       |...|.:.:| :...||.:||       .||....|.|....
Mouse  1125 DVEDGGYYSCVAFNGQDRDQRWVQLRVLRELT-ITGLPPAVTV-------AEGDTARLLCVVAG- 1180

  Fly   268 PKSINY-WTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINP--------LTQAEFGSYRCVA 321
             :|:|. |:|....|...|                .|:|.:|        |...:.|||.|.|
Mouse  1181 -ESVNIRWSRNGLPIQADG----------------HRVHQSPDGTLLIHNLRPRDEGSYTCSA 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845
		IG_like	51..137	CDD:214653
		IG_like	153..237	CDD:214653	25/90 (28%)
		Ig	161..224	CDD:299845	20/62 (32%)
		IG_like	252..335	CDD:214653	19/79 (24%)
		Ig	258..333	CDD:143165	17/73 (23%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064
		I-set	1070..1141	CDD:369462	24/80 (30%)
		Ig	1157..1241	CDD:386229	23/95 (24%)
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900