DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-eta and Dscam

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	390	Identity:	106/390 - (27%)
Similarity:	169/390 - (43%)	Gaps:	55/390 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YPQRVEV--PAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHV 91
            |..|:.|  ||.:       .|:.|:||..|||.::.|.|.....|.:.|.:  ...:|.. ||
Mouse   495 YQARINVRGPASI-------RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK--NANLLPF-NH- 548

  Fly    92 ITKNQRIGIANSEHKTWTMRIKDI-KESDKGWYMCQINTDPM--KSQMGYLDVVVPPDI--LDYP 151
                :::...|:    .|:::.|: ||.|:|.|.|.:...|.  .||..::.|.|||.|  .::|
Mouse   549 ----RQVAFENN----GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605

  Fly   152 TSTDMVVREGSNVTLKCAATGSPEP-TITWRRESGVPIELATGEEVMSIEGT-DLVIPNVRRHHM 214
            ..:     .|..|.:.|.......| ||||::: |.||..:.|..:.:|:.| .|.|.|:...|.
Mouse   606 RFS-----IGQRVFIPCVVVSGDLPITITWQKD-GRPIPASLGVTIDNIDFTSSLRISNLSLMHN 664

  Fly   215 GAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERG 279
            |.|.|||.|.. .:|..:..|:|..||...||.:....:.||.|.|:|.:|.||.....|...:|
Mouse   665 GNYTCIARNEA-AAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKG 728

  Fly   280 EIVPPGGKYSAN----VTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLY---RI 337
            ..||.....:.|    |...|.      |.|..:.:.:.|.|.|...|.:| .|.:..:|   :|
Mouse   729 AGVPQFQPIALNGRIQVLSNGS------LLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTVKI 786

  Fly   338 PPNAVNYVENFEARHKGKKRTKSSESH--HPARAQEHSGEDMENPGKRKADLS---LGAESIDSI 397
            |....:| .|.....:|:::..|..:|  .|...:....:.:.||...:..:|   :|.|.|.::
Mouse   787 PAMITSY-PNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTL 850

Fly 398 397
Mouse 851 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	25/92 (27%)
		IG_like	51..137	CDD:214653	25/88 (28%)
		IG_like	153..237	CDD:214653	26/85 (31%)
		Ig	161..224	CDD:299845	23/64 (36%)
		IG_like	252..335	CDD:214653	23/86 (27%)
		Ig	258..333	CDD:143165	21/78 (27%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822
		IGc2	518..575	CDD:197706	18/68 (26%)
		Ig	596..686	CDD:386229	30/96 (31%)
		Ig_DSCAM	707..784	CDD:143211	22/83 (27%)
		Ig	802..889	CDD:386229	10/49 (20%)
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810