DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and EMB

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_940851.1	Gene:	EMB / 133418	HGNCID:	30465	Length:	327	Species:	Homo sapiens

Alignment Length:	290	Identity:	72/290 - (24%)
Similarity:	110/290 - (37%)	Gaps:	62/290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 PTSTDMVVREGSNVTLKCAATGSPE---PTITWRRESGVPIE-----LATGEEVMSIEGTDLVIP 207
            |...::.:...|||.|.|..|.|.:   ..:||::: |..:|     .|||..:.    |.....
Human    71 PVEKNITLERPSNVNLTCQFTTSGDLNAVNVTWKKD-GEQLENNYLVSATGSTLY----TQYRFT 130

  Fly   208 NVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESE-AYPKSI 271
            .:....||:|.|....    ...:|.|.....|.:......||..| |....|.|:.: .:|  :
Human   131 IINSKQMGSYSCFFRE----EKEQRGTFNFKVPELHGKNKPLISYV-GDSTVLTCKCQNCFP--L 188

  Fly   272 NY-WTRERGEIVPPGG----KYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGT 331
            |: |....|.:..|.|    ||..|    |.|.|..:|.|..|.:.:..||.|.|...||:::..
Human   189 NWTWYSSNGSVKVPVGVQMNKYVIN----GTYANETKLKITQLLEEDGESYWCRALFQLGESEEH 249

  Fly   332 IKL----YRIP--PNAVNYVENFE--------ARHKGKKRTKSSESHHPARAQEHSGEDMENPGK 382
            |:|    |.:|  |..|...|...        .::..||:..|.|           |::.|...:
Human   250 IELVVLSYLVPLKPFLVIVAEVILLVATILLCEKYTQKKKKHSDE-----------GKEFEQIEQ 303

  Fly   383 RKADLSLGAESIDSIYGNSAAGSRRRQDLG 412
            .|:|.|.|.|       |:....|:.:.||
Human   304 LKSDDSNGIE-------NNVPRHRKNESLG 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845
		IG_like	51..137	CDD:214653
		IG_like	153..237	CDD:214653	21/91 (23%)
		Ig	161..224	CDD:299845	19/70 (27%)
		IG_like	252..335	CDD:214653	27/92 (29%)
		Ig	258..333	CDD:143165	23/80 (29%)
EMB	NP_940851.1	Ig	82..143	CDD:325142	18/65 (28%)
		IG_like	172..254	CDD:214653	27/88 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327		15/58 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910