DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and Dcc

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_031857.2	Gene:	Dcc / 13176	MGIID:	94869	Length:	1447	Species:	Mus musculus

Alignment Length:	339	Identity:	74/339 - (21%)
Similarity:	129/339 - (38%)	Gaps:	97/339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KFSSPIVNMTAPVGRDAFLTCVV--------------QDLGPYKVAWLRVDTQTILTIQNHVITK 94
            :|.|...::||.:|....|.|.|              |||.|     |..|::.::.
Mouse   141 RFLSQTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNP-----LPGDSRVVVL-------- 192

  Fly    95 NQRIGIANSEHKTWTMRIKDIKESDKGWYMC----------------QINTDP-MKSQMGYLDVV 142
                       .:..::|..::..|.|.|.|                :|.:|| :..|:.:|.
Mouse   193 -----------PSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQ-- 244

  Fly   143 VPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIE------- 200
                     ..::::..||.:..|:|..:|.|.|:.||.|          ||||:.:.
Mouse   245 ---------RPSNVIAIEGKDAVLECCVSGYPPPSFTWLR----------GEEVIQLRSKKYSLL 290

  Fly   201 -GTDLVIPNVRRHHMGAYLCIAS-NGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCE 263
             |::|:|.||.....|.|.|:.: .....|.|..:|::|  ||........:.|.|...:..:|.
Mouse   291 GGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLV--PPWFLNHPSNLYAYESMDIEFECA 353

  Fly   264 SEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDT 328
            ....|.....|.: .|::|.|...:..    :||    ..|.|..:.:::.|.|:|||:|..|:.
Mouse   354 VSGKPVPTVNWMK-NGDVVIPSDYFQI----VGG----SNLRILGVVKSDEGFYQCVAENEAGNA 409

  Fly   329 DGTIKLYRIPPNAV 342
            ..:.:|. :|..|:
Mouse   410 QSSAQLI-VPKPAI 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	22/120 (18%)
		IG_like	51..137	CDD:214653	21/116 (18%)
		IG_like	153..237	CDD:214653	25/92 (27%)
		Ig	161..224	CDD:299845	21/71 (30%)
		IG_like	252..335	CDD:214653	19/82 (23%)
		Ig	258..333	CDD:143165	17/74 (23%)
Dcc	NP_031857.2	Ig1_Neogenin	42..136	CDD:143199
		IG_like	46..136	CDD:214653
		IG_like	147..224	CDD:214653	17/100 (17%)
		IGc2	153..219	CDD:197706	15/89 (17%)
		I-set	241..327	CDD:254352	25/106 (24%)
		Ig	244..327	CDD:299845	24/103 (23%)
		I-set	331..417	CDD:254352	21/95 (22%)
		Ig	347..417	CDD:299845	18/79 (23%)
		FN3	429..521	CDD:238020
		FN3	528..617	CDD:238020
		FN3	625..715	CDD:238020
		FN3	726..805	CDD:214495
		FN3	846..939	CDD:238020
		FN3	946..1041	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1153
		Neogenin_C	1148..1445	CDD:284094
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1220
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1291..1329
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910