DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-eta and AgaP_AGAP007092

DIOPT Version :9

Sequence 1:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_308666.4	Gene:	AgaP_AGAP007092 / 1270011	VectorBaseID:	AGAP007092	Length:	1805	Species:	Anopheles gambiae

Alignment Length:	395	Identity:	102/395 - (25%)
Similarity:	166/395 - (42%)	Gaps:	62/395 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CYPQ----RVEVPAEVIVDPKFSSPIV----NMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTI 84
            |..|    ||...|:|.:   :..|.:    .:|...|.|..:.|.|......|:.|.| |.||:
Mosquito   364 CVAQNSIGRVSHSAKVNI---YGLPYIREMPKITGVSGHDLIIKCPVAGYPIDKIHWER-DGQTL 424

  Fly    85 LTIQNHVITKNQRIGIANSEHKTWTMRIKDIK-ESDKGWYMCQINTDPMKSQMGYLD--VVVPPD 146
                  .|.:.||      .:...|:.|:.:: ..|.|.|.|.......::....::  |:|||.
Mosquito   425 ------PINRRQR------AYNNGTLIIEQLQLAEDAGTYTCMAQNKQKQTARRNVEIQVIVPPK 477

  Fly   147 ILDYPTSTDMVVREGSNVTLKCAATGSPEP-TITWRRESGVPIELATGEEV---MSIEGTDLVIP 207
            |:.....|:| :|||....:.|.......| ...|.| :|.|: |.||.||   :....|.|||.
Mosquito   478 IMPIQAMTNM-LREGMRAAISCQILEGDLPVNFRWER-NGKPV-LGTGNEVIRRLDEYSTSLVIE 539

  Fly   208 NVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSIN 272
            ::...:.|.|.||||| |..|.|..:.|.|:.||...::.:...|..|:.|.|.|::..:|:...
Mosquito   540 HITSEYSGNYTCIASN-VAGSESFTVPLTVNVPPKWILEPKDSSAQAGQDVALHCQAGGHPQPTV 603

  Fly   273 YWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHIN------PLTQAEFGSYRCVAKNSLGDTDGT 331
            .|.:..|. .|  |:|...:     |..::.||.|      .:.:...|.:.|.||||:|  .|.
Mosquito   604 TWKKAIGN-TP--GEYKDFL-----YEPNVSLHTNGTLQFRKIAKDSQGHFLCEAKNSIG--TGV 658

  Fly   332 IKLYRIPPNAVNYVENFEARHKGKKRTKSSESHHPARAQEHSGEDME---NPGKRKADLSLGAES 393
            .|:..:   .||...:|..::|.....::.:.|.....|..:..|::   ...:::.|     ||
Mosquito   659 SKVIFL---KVNVPAHFTTKNKQITSPRNKQIHIQCNVQGDNPIDIKWKMQSSQQQLD-----ES 715

  Fly   394 IDSIY 398
            :|:.|
Mosquito   716 LDNRY 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	20/92 (22%)
		IG_like	51..137	CDD:214653	20/86 (23%)
		IG_like	153..237	CDD:214653	31/87 (36%)
		Ig	161..224	CDD:299845	22/66 (33%)
		IG_like	252..335	CDD:214653	24/88 (27%)
		Ig	258..333	CDD:143165	21/80 (26%)
AgaP_AGAP007092	XP_308666.4	IG	3..71	CDD:214652
		IG	108..188	CDD:214652
		Ig	115..185	CDD:143165
		IG_like	198..278	CDD:214653
		IGc2	206..268	CDD:197706
		IG	294..381	CDD:214652	6/16 (38%)
		Ig	304..378	CDD:143165	4/13 (31%)
		IG	391..472	CDD:214652	20/93 (22%)
		IGc2	397..459	CDD:197706	19/74 (26%)
		IG_like	489..568	CDD:214653	29/81 (36%)
		Ig	496..564	CDD:143165	25/70 (36%)
		I-set	572..666	CDD:254352	25/106 (24%)
		Ig	589..666	CDD:299845	22/89 (25%)
		I-set	671..767	CDD:254352	10/55 (18%)
		Ig	689..774	CDD:299845	7/37 (19%)
		FN3	771..864	CDD:238020
		FN3	871..975	CDD:238020
		FN3	982..1075	CDD:238020
		FN3	1080..1172	CDD:238020
		IGc2	1195..1256	CDD:197706
		FN3	1269..1359	CDD:238020
		FN3	1364..1445	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810